Mettl1 methyltransferase 1, tRNA methylguanosine [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mettl1provided by MGI
Official Full Name: methyltransferase 1, tRNA methylguanosineprovided by MGI
Primary source: MGI:MGI:1339986
See related: Ensembl:ENSMUSG00000006732 AllianceGenome:MGI:1339986
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810012D02Rik
Summary: Predicted to enable internal mRNA (guanine-N7-)-methyltransferase activity and tRNA (guanine(46)-N7)-methyltransferase activity. Predicted to be involved in tRNA (guanine-N7)-methylation and tRNA stabilization. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of tRNA (m7G46) methyltransferase complex. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 10.7), placenta adult (RPKM 9.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 74.5 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (126877287..126882234)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (127041549..127046365)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.
Title: The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.
Eliminating METTL1-mediated accumulation of PMN-MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation.
Title: Eliminating METTL1-mediated accumulation of PMN-MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation.
METTL1 acts as a methyltransferase for a subset of internal N(7)-methylguanosine sites in mRNA.
Title: Transcriptome-wide Mapping of Internal N(7)-Methylguanosine Methylome in Mammalian mRNA.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables internal mRNA (guanine-N7-)-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables internal mRNA (guanine-N7-)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA (guanine(46)-N7)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA (guanine(46)-N7)-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables tRNA (guanine(46)-N7)-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA (guanine-N7)-methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA (guanine-N7)-methylation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to stress	IEA Inferred from Electronic Annotation more info
involved_in tRNA (guanine-N7)-methylation	ISO Inferred from Sequence Orthology more info
involved_in tRNA (guanine-N7)-methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA modification	ISO Inferred from Sequence Orthology more info
involved_in tRNA modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA stabilization	IEA Inferred from Electronic Annotation more info
involved_in tRNA stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of tRNA (m7G46) methyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of tRNA (m7G46) methyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of tRNA methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tRNA (guanine-N(7)-)-methyltransferase

Names: mRNA (guanine-N(7)-)-methyltransferase; methyltransferase like 1; miRNA (guanine-N(7)-)-methyltransferase

NP_034922.1

EC 2.1.1.33

XP_006513375.1

EC 2.1.1.33

XP_006513376.1

EC 2.1.1.33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010792.1 → NP_034922.1 tRNA (guanine-N(7)-)-methyltransferase

See identical proteins and their annotated locations for NP_034922.1

Status: PROVISIONAL

Source sequence(s)

AB023619

Consensus CDS

CCDS24223.1

UniProtKB/Swiss-Prot

Q3TU83, Q921G5, Q9Z120

Related

ENSMUSP00000006915.8, ENSMUST00000006915.14

Conserved Domains (1) summary

pfam02390
Location:71 → 248

Methyltransf_4; Putative methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

126877287..126882234

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513312.3 → XP_006513375.1 tRNA (guanine-N(7)-)-methyltransferase isoform X1

Conserved Domains (1) summary

pfam02390
Location:118 → 295

Methyltransf_4; Putative methyltransferase
XM_006513313.4 → XP_006513376.1 tRNA (guanine-N(7)-)-methyltransferase isoform X2

UniProtKB/TrEMBL

D3Z7D2

Related

ENSMUSP00000113030.2, ENSMUST00000120542.8

Conserved Domains (1) summary

cl17173
Location:118 → 232

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...