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    Asb16 ankyrin repeat and SOCS box-containing 16 [ Mus musculus (house mouse) ]

    Gene ID: 217217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asb16provided by MGI
    Official Full Name
    ankyrin repeat and SOCS box-containing 16provided by MGI
    Primary source
    MGI:MGI:2654437
    See related
    Ensembl:ENSMUSG00000034768 AllianceGenome:MGI:2654437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB16 (ankyrin repeat and SOCS box containing 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 6.5), colon adult (RPKM 1.6) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Asb16 in Genome Data Viewer
    Location:
    11 D; 11 66.29 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102159577..102170280)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102268751..102279454)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene histone deacetylase 5 Neighboring gene STARR-positive B cell enhancer ABC_E378 Neighboring gene microRNA 8101 Neighboring gene STARR-positive B cell enhancer ABC_E911 Neighboring gene homologous recombination factor with OB-fold Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102128926-102129035 Neighboring gene STARR-positive B cell enhancer ABC_E1432 Neighboring gene transmembrane and ubiquitin-like domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102156604-102156807 Neighboring gene STARR-positive B cell enhancer ABC_E469 Neighboring gene ataxin 7-like 3 Neighboring gene predicted gene, 33851

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and SOCS box protein 16
    Names
    ASB-16
    ankyrin repeat domain-containing SOCS box protein Asb-16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148953.3 → NP_683755.1  ankyrin repeat and SOCS box protein 16

      See identical proteins and their annotated locations for NP_683755.1

      Status: VALIDATED

      Source sequence(s)
      AL954730
      Consensus CDS
      CCDS25493.1
      UniProtKB/Swiss-Prot
      Q8BYT0, Q8VHS5
      UniProtKB/TrEMBL
      A1L0X7
      Related
      ENSMUSP00000038450.5, ENSMUST00000036467.5
      Conserved Domains (4) summary
      cd00204
      Location:114 → 228
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd03716
      Location:406 → 446
      SOCS_ASB_like; SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable ...
      pfam12796
      Location:115 → 204
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:114 → 140
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102159577..102170280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHS5.1 GenPept UniProtKB/Swiss-Prot:Q8VHS5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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