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    Ewsr1 Ewing sarcoma breakpoint region 1 [ Mus musculus (house mouse) ]

    Gene ID: 14030, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ewsr1provided by MGI
    Official Full Name
    Ewing sarcoma breakpoint region 1provided by MGI
    Primary source
    MGI:MGI:99960
    See related
    Ensembl:ENSMUSG00000009079 AllianceGenome:MGI:99960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ews; Ewsh
    Summary
    Predicted to enable RNA binding activity; identical protein binding activity; and transcription coregulator activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in Ewing sarcoma. Orthologous to human EWSR1 (EWS RNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 109.2), thymus adult (RPKM 93.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ewsr1 in Genome Data Viewer
    Location:
    11 A1; 11 3.22 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (5019687..5049314, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (5069687..5099107, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene adaptor protein complex AP-1, beta 1 subunit Neighboring gene predicted gene, 24958 Neighboring gene growth arrest-specific 2 like 1 Neighboring gene RAS-like, family 10, member A Neighboring gene STARR-positive B cell enhancer ABC_E8383 Neighboring gene STARR-positive B cell enhancer ABC_E11468 Neighboring gene rhomboid domain containing 3 Neighboring gene EMI domain containing 1 Neighboring gene predicted gene, 46266 Neighboring gene predicted gene, 39572

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling. Jung JW, et al. Sci Rep, 2023 Sep 14. PMID 37709831, Free PMC Article
    2. Cloning and chromosome localization of the mouse Ews gene. Plougastel B, et al. Genomics, 1994 Sep 1. PMID 7829090
    3. The Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells. Codrington R, et al. PLoS Biol, 2005 Aug. PMID 15974803, Free PMC Article
    4. Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development. Li H, et al. J Clin Invest, 2007 May. PMID 17415412, Free PMC Article
    5. A multifunctional protein EWS regulates the expression of Drosha and microRNAs. Kim KY, et al. Cell Death Differ, 2014 Jan. PMID 24185621, Free PMC Article

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling.
      Title: In-depth proteome analysis of brain tissue from Ewsr1 knockout mouse by multiplexed isobaric tandem mass tag labeling.
    2. Gammaherpesvirus-mediated repression reveals EWSR1 to be a negative regulator of B cell responses.
      Title: Gammaherpesvirus-mediated repression reveals EWSR1 to be a negative regulator of B cell responses.
    3. Expression of the EWSR1-FLI1 fusion oncogene in pancreas cells drives pancreatic atrophy and lipomatosis.
      Title: Expression of the EWSR1-FLI1 fusion oncogene in pancreas cells drives pancreatic atrophy and lipomatosis.
    4. EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8.
      Title: EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8.
    5. Mouse EWSR1 is crucial for spermatid post-meiotic transcription and spermiogenesis.
      Title: Mouse EWSR1 is crucial for spermatid post-meiotic transcription and spermiogenesis.
    6. we show that loss of Stag2 cooperates with EWS-FLI1 and p53 mutation to promote sarcomagenesis in murine MSCs
      Title: Loss of Stag2 cooperates with EWS-FLI1 to transform murine Mesenchymal stem cells.
    7. the Fox transcription factor binding motif was frequently observed within EWS-FLI1 peaks and Foxq1 was identified as the cooperative partner that interacts with the EWS portion of EWS-FLI1.
      Title: EWS-FLI1 regulates a transcriptional program in cooperation with Foxq1 in mouse Ewing sarcoma.
    8. Authors found that FUS, EWS and TAF15 expression is differentially regulated during brain development, both in time and in space. In particular, this study identifies a fine-tuned regulation of FUS and EWS during neuronal differentiation.
      Title: Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation.
    9. Gnai1 function is impaired in the spinal cord of Ews/Ewsr1 KO mice
      Title: Integrated analysis of omics data using microRNA-target mRNA network and PPI network reveals regulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice.
    10. EWS is normally O-GlcNAc glycosylated in the brain.
      Title: O-GlcNAc glycosylation stoichiometry of the FET protein family: only EWS is glycosylated with a high stoichiometry.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (9)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein EWS
    Names
    Ewing sarcoma homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001283061.2 → NP_001269990.1  RNA-binding protein EWS isoform 1

      See identical proteins and their annotated locations for NP_001269990.1

      Status: VALIDATED

      Source sequence(s)
      AI852718, AK046434, BC068226, BY272748, CB205713
      UniProtKB/TrEMBL
      Q3UI30, Q6NVA3
      Conserved Domains (4) summary
      COG0724
      Location:354 → 455
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:361 → 444
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:522 → 543
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:518 → 547
      zf-RanBP; Zn-finger in Ran binding protein and others

    2. NM_001283062.2 → NP_001269991.1  RNA-binding protein EWS isoform 3

      Status: VALIDATED

      Source sequence(s)
      AI852718, AK046434, AK049743, AL645845, BY272748
      Consensus CDS
      CCDS70131.1
      UniProtKB/TrEMBL
      Q3UI30, Q5SUT0
      Related
      ENSMUSP00000073034.5, ENSMUST00000073308.11
      Conserved Domains (4) summary
      COG0724
      Location:316 → 417
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:323 → 406
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:484 → 505
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:480 → 509
      zf-RanBP; Zn-finger in Ran binding protein and others

    3. NM_001283063.2 → NP_001269992.1  RNA-binding protein EWS isoform 4

      See identical proteins and their annotated locations for NP_001269992.1

      Status: VALIDATED

      Source sequence(s)
      AK046434, AK147909, BY272748
      UniProtKB/TrEMBL
      Q3UGI7

    4. NM_001362612.1 → NP_001349541.1  RNA-binding protein EWS isoform 5

      Status: VALIDATED

      Source sequence(s)
      AI852718, AL645845
      UniProtKB/TrEMBL
      Q3UI30
      Conserved Domains (4) summary
      cd12533
      Location:367 → 450
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:528 → 549
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:524 → 553
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl27818
      Location:52 → 159
      COG1615; Uncharacterized membrane protein, UPF0182 family [Function unknown]

    5. NM_001362613.1 → NP_001349542.1  RNA-binding protein EWS isoform 6

      Status: VALIDATED

      Source sequence(s)
      AI852718, AL645845
      UniProtKB/TrEMBL
      Q3UI30
      Conserved Domains (4) summary
      cd12533
      Location:367 → 450
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:528 → 549
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:524 → 553
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl27818
      Location:53 → 160
      COG1615; Uncharacterized membrane protein, UPF0182 family [Function unknown]

    6. NM_001362614.1 → NP_001349543.1  RNA-binding protein EWS isoform 7

      Status: VALIDATED

      Source sequence(s)
      AI852718, AL645845
      Consensus CDS
      CCDS88124.1
      UniProtKB/TrEMBL
      Q3UI30, Q5SUS9
      Related
      ENSMUSP00000099994.4, ENSMUST00000102930.10
      Conserved Domains (4) summary
      cd12533
      Location:366 → 449
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:527 → 548
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:523 → 552
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl27818
      Location:52 → 159
      COG1615; Uncharacterized membrane protein, UPF0182 family [Function unknown]

    7. NM_001362615.1 → NP_001349544.1  RNA-binding protein EWS isoform 8

      Status: VALIDATED

      Source sequence(s)
      AI852718, AL645845
      UniProtKB/TrEMBL
      Q3UI30
      Conserved Domains (4) summary
      cd12533
      Location:365 → 448
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:526 → 547
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:522 → 551
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl26247
      Location:10 → 140
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    8. NM_001362616.1 → NP_001349545.1  RNA-binding protein EWS isoform 9

      Status: VALIDATED

      Source sequence(s)
      AI852718, AL645845
      UniProtKB/TrEMBL
      Q3UI30
      Conserved Domains (4) summary
      cd12533
      Location:329 → 412
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:490 → 511
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:486 → 515
      zf-RanBP; Zn-finger in Ran binding protein and others
      cl27818
      Location:52 → 159
      COG1615; Uncharacterized membrane protein, UPF0182 family [Function unknown]

    9. NM_001362617.1 → NP_001349546.1  RNA-binding protein EWS isoform 10

      Status: VALIDATED

      Source sequence(s)
      AI852718, AL645845
      UniProtKB/TrEMBL
      Q3UI30
      Conserved Domains (2) summary
      cd12533
      Location:360 → 443
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      cl26247
      Location:10 → 135
      DNA_pol3_delta2; DNA polymerase III, delta subunit

    10. NM_001362618.1 → NP_001349547.1  RNA-binding protein EWS isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL645845

    11. NM_001362620.1 → NP_001349549.1  RNA-binding protein EWS isoform 12

      Status: VALIDATED

      Source sequence(s)
      AI852718, AL645845
      UniProtKB/TrEMBL
      Q9CRS5
      Conserved Domains (3) summary
      sd00025
      Location:183 → 204
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:179 → 208
      zf-RanBP; Zn-finger in Ran binding protein and others
      cd12533
      Location:22 → 105
      RRM_EWS; RNA recognition motif (RRM) found in vertebrate Ewing Sarcoma Protein (EWS)

    12. NM_001430960.1 → NP_001417889.1  RNA-binding protein EWS isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL645845

    13. NM_001430961.1 → NP_001417890.1  RNA-binding protein EWS isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL645845

    14. NM_007968.4 → NP_031994.2  RNA-binding protein EWS isoform 2

      See identical proteins and their annotated locations for NP_031994.2

      Status: VALIDATED

      Source sequence(s)
      AI852718, AK046434, AK151625, BY272748, CB205713
      Consensus CDS
      CCDS24396.1
      UniProtKB/Swiss-Prot
      Q61545, Q9D2P0
      UniProtKB/TrEMBL
      Q3UI30
      Related
      ENSMUSP00000078867.7, ENSMUST00000079949.13
      Conserved Domains (4) summary
      COG0724
      Location:353 → 454
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12533
      Location:360 → 443
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:521 → 542
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:517 → 546
      zf-RanBP; Zn-finger in Ran binding protein and others

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      5019687..5049314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006514510.4 → XP_006514573.1  RNA-binding protein EWS isoform X3

      Conserved Domains (4) summary
      PRK14949
      Location:10 → 135
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      cd12533
      Location:361 → 444
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:522 → 543
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:519 → 547
      zf-RanBP; Zn-finger in Ran binding protein and others

    2. XM_017314255.3 → XP_017169744.1  RNA-binding protein EWS isoform X4

      Conserved Domains (4) summary
      PRK14949
      Location:10 → 135
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
      cd12533
      Location:360 → 443
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:521 → 542
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:518 → 546
      zf-RanBP; Zn-finger in Ran binding protein and others

    3. XM_006514509.2 → XP_006514572.1  RNA-binding protein EWS isoform X2

      UniProtKB/TrEMBL
      Q3UI30
      Conserved Domains (4) summary
      PRK12438
      Location:52 → 159
      PRK12438; hypothetical protein; Provisional
      cd12533
      Location:366 → 449
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:527 → 548
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:524 → 552
      zf-RanBP; Zn-finger in Ran binding protein and others

    4. XM_006514508.2 → XP_006514571.1  RNA-binding protein EWS isoform X1

      UniProtKB/TrEMBL
      Q3UI30
      Conserved Domains (4) summary
      PRK12438
      Location:52 → 159
      PRK12438; hypothetical protein; Provisional
      cd12533
      Location:367 → 450
      RRM_EWS; RNA recognition motif in vertebrate Ewing Sarcoma Protein (EWS)
      sd00025
      Location:528 → 549
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:525 → 553
      zf-RanBP; Zn-finger in Ran binding protein and others

    5. XM_030245550.2 → XP_030101410.1  RNA-binding protein EWS isoform X5

      UniProtKB/TrEMBL
      Q5SUS8
      Related
      ENSMUSP00000091057.6, ENSMUST00000093365.12

    RNA

    1. XR_001779874.1 RNA Sequence

    2. XR_003949296.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61545.2 GenPept UniProtKB/Swiss-Prot:Q61545

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