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    Zbed3 zinc finger, BED type containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 72114, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zbed3provided by MGI
    Official Full Name
    zinc finger, BED type containing 3provided by MGI
    Primary source
    MGI:MGI:1919364
    See related
    Ensembl:ENSMUSG00000041995 AllianceGenome:MGI:1919364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0610037K01Rik; 2610005H11Rik
    Summary
    This gene encodes a member of the zinc finger protein superfamily. This protein may regulate the Wnt/beta-catenin signaling pathway. This protein may be involved in insulin resistance and type 2 diabetes in humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Broad expression in ovary adult (RPKM 63.5), limb E14.5 (RPKM 22.0) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbed3 in Genome Data Viewer
    Location:
    13 D1; 13 49.38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95460113..95474350)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95323605..95337842)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 41 Neighboring gene predicted gene, 48350 Neighboring gene phosphodiesterase 8B Neighboring gene predicted gene, 41025 Neighboring gene STARR-positive B cell enhancer ABC_E10808 Neighboring gene STARR-positive B cell enhancer mm9_chr13:96117046-96117346 Neighboring gene small nucleolar RNA, H/ACA box 47 Neighboring gene predicted gene, 22661 Neighboring gene predicted gene, 53806 Neighboring gene STARR-positive B cell enhancer ABC_E7266 Neighboring gene angiogenic factor with G patch and FHA domains 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zbed3 contributes to malignant phenotype of lung cancer via regulating β-catenin and P120-catenin 1. Fan C, et al. Mol Carcinog, 2015 Jun. PMID 25263389
    2. Zinc-finger BED domain-containing 3 (Zbed3) is a novel secreted protein associated with insulin resistance in humans. Jia Y, et al. J Intern Med, 2014 May. PMID 24283382
    3. Zbed3 Is Indispensable for Wnt Signaling Regulation of Cortical Layers Formation in Developing Brain. Ruan X, et al. Cereb Cortex, 2021 Jul 29. PMID 33822906
    4. Long noncoding RNA ZBED3-AS1 restrains breast cancer progression by targeting the microRNA-513a-5p/KLF6 axis. Fu A, et al. Thorac Cancer, 2021 Oct. PMID 34427978, Free PMC Article
    5. The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution. Qin D, et al. Development, 2019 Oct 18. PMID 31575650

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zbed3 Is Indispensable for Wnt Signaling Regulation of Cortical Layers Formation in Developing Brain.
      Title: Zbed3 Is Indispensable for Wnt Signaling Regulation of Cortical Layers Formation in Developing Brain.
    2. Long noncoding RNA ZBED3-AS1 restrains breast cancer progression by targeting the microRNA-513a-5p/KLF6 axis.
      Title: Long noncoding RNA ZBED3-AS1 restrains breast cancer progression by targeting the microRNA-513a-5p/KLF6 axis.
    3. The loss of maternal Zbed3 results in asymmetric zygotic division and abnormal distributions of organelles in the affected oocytes and zygotes, similar to the phenotypes observed in females with disrupted core subcortical maternal complex genes.
      Title: Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles.
    4. Zbed3 is a novel Axin-binding protein that is involved in Wnt/beta-catenin signaling modulation.
      Title: Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to glucose ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to insulin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to insulin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger BED domain-containing protein 3
    Names
    axin-interacting protein
    zinc finger, BED domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302538.1 → NP_001289467.1  zinc finger BED domain-containing protein 3

      See identical proteins and their annotated locations for NP_001289467.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK162164, AK162256, BC085478
      Consensus CDS
      CCDS26696.1
      UniProtKB/Swiss-Prot
      Q9D0L1
      UniProtKB/TrEMBL
      Q3TSB2, Q3UTC5
      Related
      ENSMUSP00000152153.2, ENSMUST00000221807.2
      Conserved Domains (2) summary
      smart00614
      Location:37 → 91
      ZnF_BED; BED zinc finger
      PRK12704
      Location:136 → 189
      PRK12704; phosphodiesterase; Provisional

    2. NM_001302539.1 → NP_001289468.1  zinc finger BED domain-containing protein 3

      See identical proteins and their annotated locations for NP_001289468.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC133188, AK162164, BC085478, BY093894
      Consensus CDS
      CCDS26696.1
      UniProtKB/Swiss-Prot
      Q9D0L1
      UniProtKB/TrEMBL
      Q3TSB2, Q3UTC5
      Conserved Domains (2) summary
      smart00614
      Location:37 → 91
      ZnF_BED; BED zinc finger
      PRK12704
      Location:136 → 189
      PRK12704; phosphodiesterase; Provisional

    3. NM_028106.3 → NP_082382.1  zinc finger BED domain-containing protein 3

      See identical proteins and their annotated locations for NP_082382.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK011319, AK162164, BC085478, BU709250, BY776906, BY776946
      Consensus CDS
      CCDS26696.1
      UniProtKB/Swiss-Prot
      Q9D0L1
      UniProtKB/TrEMBL
      Q3TSB2, Q3UTC5
      Related
      ENSMUSP00000044774.8, ENSMUST00000045909.8
      Conserved Domains (2) summary
      smart00614
      Location:37 → 91
      ZnF_BED; BED zinc finger
      PRK12704
      Location:136 → 189
      PRK12704; phosphodiesterase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      95460113..95474350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247416.2 → XP_030103276.1  zinc finger BED domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q9D0L1
      UniProtKB/TrEMBL
      Q3TSB2, Q3UTC5
      Conserved Domains (2) summary
      smart00614
      Location:37 → 91
      ZnF_BED; BED zinc finger
      PRK12704
      Location:136 → 189
      PRK12704; phosphodiesterase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0L1.1 GenPept UniProtKB/Swiss-Prot:Q9D0L1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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