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    Cby1 chibby family member 1, beta catenin antagonist [ Mus musculus (house mouse) ]

    Gene ID: 73739, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cby1provided by MGI
    Official Full Name
    chibby family member 1, beta catenin antagonistprovided by MGI
    Primary source
    MGI:MGI:1920989
    See related
    Ensembl:ENSMUSG00000022428 AllianceGenome:MGI:1920989
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CBY; arb1; Pgea1; PGEA14; 1110014P06Rik
    Summary
    Predicted to enable beta-catenin binding activity and protein homodimerization activity. Involved in cardiac muscle cell differentiation and fat cell differentiation. Acts upstream of or within cilium assembly; floor plate development; and negative regulation of canonical Wnt signaling pathway. Located in centriole and ciliary basal body. Is expressed in heart; liver; lung; and olfactory epithelium. Used to study otitis media and primary ciliary dyskinesia. Orthologous to human CBY1 (chibby 1, beta catenin antagonist). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 22.6), CNS E14 (RPKM 12.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cby1 in Genome Data Viewer
    Location:
    15 E1; 15 37.84 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79543437..79551861)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79659103..79667660)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene DNA meiotic recombinase 1 Neighboring gene family with sequence similarity 227, member A Neighboring gene STARR-seq mESC enhancer starr_39191 Neighboring gene STARR-seq mESC enhancer starr_39193 Neighboring gene predicted gene, 30877 Neighboring gene translocase of outer mitochondrial membrane 22 Neighboring gene Josephin domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein chibby homolog 1
    Names
    PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
    PKD2 interactor, golgi and endoplasmic reticulum associated 1
    chibby homolog 1
    cytosolic leucine-rich protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418672.1NP_001405601.1  protein chibby homolog 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117806, AC118227
      UniProtKB/Swiss-Prot
      Q9D1C2
    2. NM_001418673.1NP_001405602.1  protein chibby homolog 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117806, AC118227
    3. NM_001418674.1NP_001405603.1  protein chibby homolog 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117806, AC118227
    4. NM_001418676.1NP_001405605.1  protein chibby homolog 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117806, AC118227
    5. NM_028634.4NP_082910.1  protein chibby homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_082910.1

      Status: VALIDATED

      Source sequence(s)
      AC117806, AC118227
      Consensus CDS
      CCDS27645.1
      UniProtKB/Swiss-Prot
      Q9D1C2
      Related
      ENSMUSP00000023064.8, ENSMUST00000023064.9
      Conserved Domains (1) summary
      pfam14645
      Location:1114
      Chibby; Chibby family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79543437..79551861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)