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    Dmc1 DNA meiotic recombinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 13404, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dmc1provided by MGI
    Official Full Name
    DNA meiotic recombinase 1provided by MGI
    Primary source
    MGI:MGI:105393
    See related
    Ensembl:ENSMUSG00000022429 AllianceGenome:MGI:105393
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sgdp; Dmc1h; Lim15; Mei11
    Summary
    This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. In mouse, deficiency of this gene causes infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
    Expression
    Biased expression in limb E14.5 (RPKM 2.8), testis adult (RPKM 2.6) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dmc1 in Genome Data Viewer
    Location:
    15 E1; 15 37.79 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79445698..79489362, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79561497..79605159, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4 Neighboring gene STARR-seq mESC enhancer starr_39188 Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 Neighboring gene STARR-seq mESC enhancer starr_39189 Neighboring gene DEAD box helicase 17 Neighboring gene family with sequence similarity 227, member A Neighboring gene STARR-seq mESC enhancer starr_39191 Neighboring gene STARR-seq mESC enhancer starr_39193 Neighboring gene predicted gene, 30877 Neighboring gene chibby family member 1, beta catenin antagonist

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC151144

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent activity, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA strand exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA strand exchange activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA strand exchange activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in DNA recombinase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA strand invasion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromosome organization involved in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in double-strand break repair involved in meiotic recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within gamete generation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within oogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in reciprocal meiotic recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in reciprocal meiotic recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral element IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    meiotic recombination protein DMC1/LIM15 homolog
    Names
    DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
    disrupted meiotic cDNA 1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278226.1NP_001265155.1  meiotic recombination protein DMC1/LIM15 homolog isoform 2

      See identical proteins and their annotated locations for NP_001265155.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons in the coding region compared to variant 1. The resulting protein (isoform 2) lacks an internal portion and is shorter, compared to isoform 1.
      Source sequence(s)
      AK076777, AK169570, AV451479
      Consensus CDS
      CCDS88806.1
      UniProtKB/TrEMBL
      Q8C610
      Related
      ENSMUSP00000155228.2, ENSMUST00000229408.2
      Conserved Domains (3) summary
      TIGR02238
      Location:24283
      recomb_DMC1; meiotic recombinase Dmc1
      cd01123
      Location:101281
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      pfam14520
      Location:2579
      HHH_5; Helix-hairpin-helix domain
    2. NM_010059.3NP_034189.1  meiotic recombination protein DMC1/LIM15 homolog isoform 1

      See identical proteins and their annotated locations for NP_034189.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK169570, AV451479, BC116767
      Consensus CDS
      CCDS27644.1
      UniProtKB/Swiss-Prot
      Q61880
      UniProtKB/TrEMBL
      Q14AN8
      Related
      ENSMUSP00000023065.7, ENSMUST00000023065.8
      Conserved Domains (3) summary
      TIGR02238
      Location:24338
      recomb_DMC1; meiotic recombinase Dmc1
      cd01123
      Location:101336
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      pfam14520
      Location:2579
      HHH_5; Helix-hairpin-helix domain

    RNA

    1. NR_103477.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks five alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK169570, AV451479
      Related
      ENSMUST00000230011.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79445698..79489362 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520407.4XP_006520470.1  meiotic recombination protein DMC1/LIM15 homolog isoform X1

      Conserved Domains (1) summary
      TIGR02238
      Location:24296
      recomb_DMC1; meiotic recombinase Dmc1
    2. XM_006520408.4XP_006520471.1  meiotic recombination protein DMC1/LIM15 homolog isoform X2

      Conserved Domains (1) summary
      TIGR02238
      Location:24282
      recomb_DMC1; meiotic recombinase Dmc1

    RNA

    1. XR_004938790.1 RNA Sequence