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    Cbx7 chromobox 7 [ Mus musculus (house mouse) ]

    Gene ID: 52609, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cbx7provided by MGI
    Official Full Name
    chromobox 7provided by MGI
    Primary source
    MGI:MGI:1196439
    See related
    Ensembl:ENSMUSG00000053411 AllianceGenome:MGI:1196439
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D15Ertd417e; 1600014J01Rik
    Summary
    Enables chromatin binding activity; methylated histone binding activity; and single-stranded RNA binding activity. Acts upstream of or within sebaceous gland development. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in brain. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 23.7), placenta adult (RPKM 17.2) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cbx7 in Genome Data Viewer
    Location:
    15 E1; 15 37.85 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79800005..79855344, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79915804..79971143, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10856 Neighboring gene STARR-seq mESC enhancer starr_39199 Neighboring gene RIKEN cDNA D730005E14 gene Neighboring gene STARR-positive B cell enhancer ABC_E7391 Neighboring gene STARR-positive B cell enhancer ABC_E4141 Neighboring gene STARR-positive B cell enhancer ABC_E3147 Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 Neighboring gene STARR-seq mESC enhancer starr_39200 Neighboring gene STARR-seq mESC enhancer starr_39204 Neighboring gene STARR-positive B cell enhancer ABC_E7392 Neighboring gene STARR-positive B cell enhancer mm9_chr15:79765174-79765475 Neighboring gene STARR-positive B cell enhancer ABC_E9420 Neighboring gene VISTA enhancer mm570 Neighboring gene STARR-seq mESC enhancer starr_39213 Neighboring gene predicted gene, 53903 Neighboring gene microRNA 7213 Neighboring gene platelet derived growth factor, B polypeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of PRC1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of PcG protein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    chromobox protein homolog 7
    Names
    chromobox homolog 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144811.3NP_659060.1  chromobox protein homolog 7

      See identical proteins and their annotated locations for NP_659060.1

      Status: VALIDATED

      Source sequence(s)
      AC113595, BC042657, BQ571764
      Consensus CDS
      CCDS37143.1
      UniProtKB/Swiss-Prot
      Q8VDS3
      Related
      ENSMUSP00000105245.3, ENSMUST00000109616.9
      Conserved Domains (1) summary
      pfam00385
      Location:1360
      Chromo; Chromo (CHRromatin Organization MOdifier) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79800005..79855344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245690.3XP_011243992.1  chromobox protein homolog 7 isoform X2

      UniProtKB/TrEMBL
      A0A6M8AZW7
      Conserved Domains (2) summary
      pfam17218
      Location:188219
      CBX7_C; CBX family C-terminal motif
      cl28914
      Location:1541
      CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
    2. XM_011245691.3XP_011243993.1  chromobox protein homolog 7 isoform X3

      See identical proteins and their annotated locations for XP_011243993.1

      Conserved Domains (1) summary
      pfam17218
      Location:155186
      CBX7_C; CBX family C-terminal motif
    3. XM_006521148.4XP_006521211.1  chromobox protein homolog 7 isoform X5

      Conserved Domains (1) summary
      pfam17218
      Location:96127
      CBX7_C; CBX family C-terminal motif
    4. XM_006521147.5XP_006521210.1  chromobox protein homolog 7 isoform X4

      Conserved Domains (2) summary
      cd18646
      Location:762
      CD_Cbx7; chromodomain of chromobox homolog 7
      pfam17218
      Location:150181
      CBX7_C; CBX family C-terminal motif
    5. XM_006521144.5XP_006521207.1  chromobox protein homolog 7 isoform X1

      UniProtKB/TrEMBL
      A0A6M8AZW7, F8WHN2
      Related
      ENSMUSP00000086708.5, ENSMUST00000089293.11
      Conserved Domains (2) summary
      cd18646
      Location:762
      CD_Cbx7; chromodomain of chromobox homolog 7
      pfam17218
      Location:209240
      CBX7_C; CBX family C-terminal motif
    6. XM_011245692.4XP_011243994.1  chromobox protein homolog 7 isoform X3

      See identical proteins and their annotated locations for XP_011243994.1

      Conserved Domains (1) summary
      pfam17218
      Location:155186
      CBX7_C; CBX family C-terminal motif

    RNA

    1. XR_003951404.2 RNA Sequence

    2. XR_384025.5 RNA Sequence