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    Paqr4 progestin and adipoQ receptor family member IV [ Mus musculus (house mouse) ]

    Gene ID: 76498, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Paqr4provided by MGI
    Official Full Name
    progestin and adipoQ receptor family member IVprovided by MGI
    Primary source
    MGI:MGI:1923748
    See related
    Ensembl:ENSMUSG00000023909 AllianceGenome:MGI:1923748
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500004C10Rik
    Summary
    Enables molecular adaptor activity. Involved in protein stabilization and regulation of ceramide biosynthetic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including acetabular region; ganglia; inner ear; limb; and rib. Orthologous to human PAQR4 (progestin and adipoQ receptor family member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 104.3), large intestine adult (RPKM 48.5) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Paqr4 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.02 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23955160..23959873, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23736186..23740899, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene claudin 9 Neighboring gene glycine rich extracellular protein 1 Neighboring gene protein kinase, membrane associated tyrosine/threonine 1 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene RIKEN cDNA 9530082P21 gene Neighboring gene FLYWCH-type zinc finger 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in Breast Cancer. Pedersen L, et al. Cancer Res, 2020 Jun 1. PMID 32291319
    2. PAQR4 regulates adipocyte function and systemic metabolic health by mediating ceramide levels. Zhu Q, et al. Nat Metab, 2024 Jul. PMID 38961186
    3. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. Tang YT, et al. J Mol Evol, 2005 Sep. PMID 16044242
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of ceramide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    progestin and adipoQ receptor family member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023824.3 → NP_076313.1  progestin and adipoQ receptor family member 4

      See identical proteins and their annotated locations for NP_076313.1

      Status: PROVISIONAL

      Source sequence(s)
      AC122821
      Consensus CDS
      CCDS28461.1
      UniProtKB/Swiss-Prot
      Q3U7G1, Q9JJE4
      Related
      ENSMUSP00000024702.4, ENSMUST00000024702.5
      Conserved Domains (1) summary
      cl03831
      Location:43 → 254
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      23955160..23959873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525098.3 → XP_006525161.1  progestin and adipoQ receptor family member 4 isoform X1

      Conserved Domains (1) summary
      cl03831
      Location:20 → 187
      HlyIII; Haemolysin-III related
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJE4.1 GenPept UniProtKB/Swiss-Prot:Q9JJE4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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