Atp6v1e2 ATPase, H+ transporting, lysosomal V1 subunit E2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp6v1e2provided by MGI
Official Full Name: ATPase, H+ transporting, lysosomal V1 subunit E2provided by MGI
Primary source: MGI:MGI:1922165
See related: Ensembl:ENSMUSG00000053375 AllianceGenome:MGI:1922165
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: E1; Atp6e1; 4930500C14Rik
Summary: Enables proton-transporting ATPase activity, rotational mechanism. Acts upstream of or within proton transmembrane transport. Located in acrosomal vesicle. Orthologous to human ATP6V1E2 (ATPase H+ transporting V1 subunit E2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 67.0) See more
Orthologs: human all
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Genomic context

Location:: 17 E4; 17 56.9 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (87251537..87255315, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (86944109..86947887, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

novel isoform of V-ATPase E subunit located in the acrosomal membrane of sperm required for acrosome acidification
Title: A proton pump ATPase with testis-specific E1-subunit isoform required for acrosome acidification.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables proton-transporting ATPase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within proton transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting two-sector ATPase complex, catalytic domain	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: V-type proton ATPase subunit E 2

Names: ATPase, H+ transporting, V1 subunit E-like 2; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E-like 2; V-ATPase subunit E 2; lysosomal 31kDa; vacuolar proton pump subunit E 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.