Ttf1 transcription termination factor, RNA polymerase I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttf1provided by MGI
Official Full Name: transcription termination factor, RNA polymerase Iprovided by MGI
Primary source: MGI:MGI:105044
See related: Ensembl:ENSMUSG00000026803 AllianceGenome:MGI:105044
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TTF-1; TTF-I
Summary: Enables DNA binding activity and chromatin binding activity. Involved in termination of RNA polymerase I transcription. Acts upstream of or within chromatin remodeling and transcription initiation at RNA polymerase I promoter. Located in nucleolus and nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human TTF1 (transcription termination factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: Ttf1 (GeneID 22130) and Nkx2-1 (GeneID 21869) loci share the Ttf1 symbol/alias in common. Ttf1 is a widely used alternative name for thyroid transcription factor 1 (Nkx2-1) conflicting with the official symbol for transcription termination factor, RNA polymerase I (Ttf1). [13 Feb 2013]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 5.0), bladder adult (RPKM 3.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.38 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (28950211..28977668)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (29060199..29087656)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggest that the N-terminal repeats of mouse TTF1, and by analogy those of human TTF1, cooperate to mediate both nucleolar localization and ARF binding
Title: The Short N-Terminal Repeats of Transcription Termination Factor 1 Contain Semi-Redundant Nucleolar Localization Signals and P19-ARF Tumor Suppressor Binding Sites.
Together with results showing involvement of TTF-1 in the TNF-alpha-induced increase in interleukin 1 beta and monocyte chemotactic protein 1 production, this study suggests that TTF-1 plays an important role in the mouse hypothalamus TNF-alpha-induced inflammatory response for regulating HO-1 gene expression.
Title: Role of thyroid transcription factor-1 in transcriptional regulation of heme oxygenase-1.
this study shows that in a mouse model of thyrocyte hyperplasia, proliferating thyrocytes were thyroid transcription factor (TTF1)-positive
Title: Mechanisms and kinetics of proliferation and fibrosis development in a mouse model of thyrocyte hyperplasia.
TTF-1 is expressed in lung during different stages of development.
Title: Developmental lung expression and transcriptional regulation of claudin-6 by TTF-1, Gata-6, and FoxA2.
Interaction of TTF-I with target sites upstream and downstream of the rDNA transcription unit connects these distal DNA elements by forming a chromatin loop between the rDNA promoter and the terminators.
Title: Chromatin-specific regulation of mammalian rDNA transcription by clustered TTF-I binding sites.
ErbB4 is a critical upstream regulator of TTF-1 in type II epithelial cells and that this interaction is important for Sftpb regulation.
Title: ErbB4 is an upstream regulator of TTF-1 fetal mouse lung type II cell development in vitro.
Otp and TTF-1 are essential for the normal morphological development of the hypothalamus, including the arcuate nucleus [review]
Title: Role of homeobox genes in the hypothalamic development and energy balance.
Depletion of TTF-I recapitulates the effects of ARF on ribosomal RNA synthesis and is rescued by the introduction of a TTF-I transgene.
Title: The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I.
Mediates interaction between promoter and terminator regions, which brings the beginning and end of active ribosomal RNA genes into close contact.
Title: Epigenetic regulation of TTF-I-mediated promoter-terminator interactions of rRNA genes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

AV245725 (e-PCR)
- UniSTS:178595

X83974 (e-PCR)
- UniSTS:158938

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA replication	IEA Inferred from Electronic Annotation more info
involved_in termination of RNA polymerase I transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within termination of RNA polymerase I transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in termination of RNA polymerase I transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within transcription initiation at RNA polymerase I promoter	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription termination factor 1

Names: RNA polymerase I termination factor; transcription termination factor I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421169.1 → NP_001408098.1 transcription termination factor 1 isoform a

Status: VALIDATED

Source sequence(s)

AL845267

UniProtKB/Swiss-Prot

Q62187, Q9JKK5
NM_001421170.1 → NP_001408099.1 transcription termination factor 1 isoform b

Status: VALIDATED

Source sequence(s)

AL845267
NM_009442.2 → NP_033468.2 transcription termination factor 1 isoform a

See identical proteins and their annotated locations for NP_033468.2

Status: VALIDATED

Source sequence(s)

AK163606, BC059011, BE332152, BU757299

Consensus CDS

CCDS38089.1

UniProtKB/Swiss-Prot

Q62187, Q9JKK5

Related

ENSMUSP00000097809.4, ENSMUST00000100237.4

Conserved Domains (1) summary

pfam13921
Location:595 → 650

Myb_DNA-bind_6; Myb-like DNA-binding domain

RNA

NR_185261.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845267
NR_185262.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845267
NR_185263.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845267

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

28950211..28977668

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036160512.1 → XP_036016405.1 transcription termination factor 1 isoform X1

Conserved Domains (1) summary

pfam13921
Location:625 → 680

Myb_DNA-bind_6; Myb-like DNA-binding domain