Hspa4l heat shock protein 4 like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hspa4lprovided by MGI
Official Full Name: heat shock protein 4 likeprovided by MGI
Primary source: MGI:MGI:107422
See related: Ensembl:ENSMUSG00000025757 AllianceGenome:MGI:107422
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 94kDa; APG-1; Osp94
Summary: Predicted to enable ATP binding activity and adenyl-nucleotide exchange factor activity. Predicted to be involved in protein folding and response to unfolded protein. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; liver and biliary system; nervous system; and sensory organ. Orthologous to human HSPA4L (heat shock protein family A (Hsp70) member 4 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 20.6), cerebellum adult (RPKM 14.3) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 19.51 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (40698664..40750538)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (40744500..40796103)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heat shock protein A4L is a potent autoantigen for testicular autoimmunity in mice.
Title: Heat shock protein A4L is a potent autoantigen for testicular autoimmunity in mice.
Hspa4l-null mice showed male infertility and the malformation of sperm heads. Hspa4l enhanced the release of Ppp1cc2 from complexes with Hsp70 and Hsc70. Introduction of a Prm2 S56A mutation to Hspa4l-null mice restored the malformation of sperm heads and the infertility of Hspa4l (-/-) mice.
Title: Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo.
HSPA4L and HSPA4 collaborate in embryonic lung maturation, which is necessary for adaptation to air breathing at birth.
Title: Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice.
Under conditions of hypoxic and oxidative stress we found that Nogo-A and Apg-1 were tightly co-regulated in hippocampal neurons
Title: Nogo-A couples with Apg-1 through interaction and co-ordinate expression under hypoxic and oxidative stress.
Quantitative real-time PCR analysis also showed that transcription of the OSP94 gene in the cochlea was significantly up-regulated in the EH group.
Title: Expression of osmotic stress protein 94 in murine endolymphatic hydrops model.
Hspa4l is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.
These results provide evidence that Hspa4l is required for normal spermatogenesis and suggest that Hspa4l plays a role in osmotolerance.
Title: Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498266 (e-PCR)
- UniSTS:498266

Hspa4l (e-PCR), detects polymorphism
- UniSTS:498266

AI461691 (e-PCR)
- UniSTS:178828

Osp94 (e-PCR), detects polymorphism
- UniSTS:144098

U23921 (e-PCR)
- UniSTS:163310

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to unfolded protein	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: heat shock 70 kDa protein 4L

Names: heat shock 70-related protein APG-1; heat shock 70kDa protein 4 like; osmotic stress protein 94

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.