Tent5b terminal nucleotidyltransferase 5B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tent5bprovided by MGI
Official Full Name: terminal nucleotidyltransferase 5Bprovided by MGI
Primary source: MGI:MGI:2140500
See related: Ensembl:ENSMUSG00000046694 AllianceGenome:MGI:2140500
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam46b; 4732473B16Rik
Summary: Predicted to enable poly(A) RNA polymerase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of cell population proliferation; and positive regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Orthologous to human TENT5B (terminal nucleotidyltransferase 5B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 17.7), stomach adult (RPKM 15.3) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 66.25 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (133207444..133215251)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (133480133..133487940)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

AU045678 (e-PCR)
- UniSTS:185603

AU046069 (e-PCR)
- UniSTS:179084

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables poly(A) RNA polymerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) RNA polymerase activity	ISO Inferred from Sequence Orthology more info
enables poly(A) RNA polymerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in mRNA stabilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: terminal nucleotidyltransferase 5B

Names: family with sequence similarity 46, member B; non-canonical poly(A) polymerase FAM46B; protein FAM46B; putative nucleotidyltransferase FAM46B

NP_780516.1

EC 2.7.7.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.