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    Zfp384 zinc finger protein 384 [ Mus musculus (house mouse) ]

    Gene ID: 269800, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp384provided by MGI
    Official Full Name
    zinc finger protein 384provided by MGI
    Primary source
    MGI:MGI:2443203
    See related
    Ensembl:ENSMUSG00000038346 AllianceGenome:MGI:2443203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NP; Ciz; Nmp4; C130073D16Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SH3 domain binding activity. Predicted to be involved in nucleocytoplasmic transport; positive regulation of protein secretion; and positive regulation of transcription by RNA polymerase II. Predicted to be located in focal adhesion. Predicted to be active in nucleus. Is expressed in genitourinary system. Orthologous to human ZNF384 (zinc finger protein 384). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 25.8), thymus adult (RPKM 24.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp384 in Genome Data Viewer
    Location:
    6 F2; 6 59.17 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124985980..125014833)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (125009017..125037870)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3682 Neighboring gene COP9 signalosome subunit 7A Neighboring gene predicted gene, 23851 Neighboring gene STARR-seq mESC enhancer starr_17320 Neighboring gene STARR-seq mESC enhancer starr_17322 Neighboring gene PILR alpha associated neural protein Neighboring gene STARR-positive B cell enhancer ABC_E6488 Neighboring gene STARR-positive B cell enhancer ABC_E1711 Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124959611-124959720 Neighboring gene STARR-positive B cell enhancer ABC_E1071 Neighboring gene STARR-seq mESC enhancer starr_17323 Neighboring gene STARR-positive B cell enhancer ABC_E6489 Neighboring gene inhibitor of growth family, member 4 Neighboring gene proacrosin binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein-induced bone formation. Morinobu M, et al. J Exp Med, 2005 Mar 21. PMID 15781586, Free PMC Article
    2. Nmp4/CIZ: road block at the intersection of PTH and load. Childress P, et al. Bone, 2010 Feb. PMID 19766748, Free PMC Article
    3. Nmp4/CIZ inhibits mechanically induced beta-catenin signaling activity in osteoblasts. Yang Z, et al. J Cell Physiol, 2010 May. PMID 20112285, Free PMC Article
    4. Impaired spermatogenesis and male fertility defects in CIZ/Nmp4-disrupted mice. Nakamoto T, et al. Genes Cells, 2004 Jun. PMID 15189450
    5. Nmp4/CIZ suppresses the parathyroid hormone anabolic window by restricting mesenchymal stem cell and osteoprogenitor frequency. He Y, et al. Stem Cells Dev, 2013 Feb 1. PMID 22873745, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation.
      Title: Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation.
    2. NMP4 regulates the innate immune response to influenza A virus infection.
      Title: NMP4 regulates the innate immune response to influenza A virus infection.
    3. loss of Nmp4 increases the magnitude of glycolysis upon the metabolic switch, which fuels the conversion of the osteoblast into a super-secretor of matrix resulting in more bone with improvements in intrinsic quality.
      Title: Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality.
    4. The heightened osteoanabolism of the Nmp4-/- skeleton enhances the effectiveness of diverse osteoporosis treatments, in part by increasing hyperanabolic osteoprogenitors. Nmp4 provides a promising target pathway for identifying barriers to pharmacologically induced bone formation.
      Title: Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism.
    5. Sustained protein synthesis sensitized cells to pharmacological induction of the Unfolded Protein Response (UPR), and the observed decrease in cell viability was restored upon inhibition of GADD34 activity. We conclude that NMP4 is a key regulator of ribosome biogenesis and the UPR, which together play a central role in determining cell viability during endoplasmic reticulum stress.
      Title: Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.
    6. NMP4 deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL and MMP-3 mRNA.
      Title: Mice Deficient in CIZ/NMP4 Develop an Attenuated Form of K/BxN-Serum Induced Arthritis.
    7. Nmp4/CIZ limits the parathyroid hormone anabolic window by restricting the number of bone marrow stem, progenitor, and blood cells that support anabolic bone remodeling.
      Title: Nmp4/CIZ suppresses the parathyroid hormone anabolic window by restricting mesenchymal stem cell and osteoprogenitor frequency.
    8. The CIZ/NMP4 expression levels are correlated to the metastatic activity in divergent types of melanoma cells.
      Title: CIZ/NMP4 is expressed in B16 melanoma and forms a positive feedback loop with RANKL to promote migration of the melanoma cells.
    9. Together these results provide experimental support for the concept that Nmp4/CIZ plays an inhibitory role in the response of bone cells to mechanical stimulation induced by OFSS.
      Title: Nmp4/CIZ inhibits mechanically induced beta-catenin signaling activity in osteoblasts.
    10. Nmp4/CIZ within the context of the PTH-induced anabolic response is described.
      Title: Nmp4/CIZ: road block at the intersection of PTH and load.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleocytoplasmic transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 384
    Names
    nuclear matrix protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252083.1 → NP_001239012.1  zinc finger protein 384 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134529, AC164563, BY595967
      Consensus CDS
      CCDS57448.1
      UniProtKB/TrEMBL
      A0AA74KTG5, E9Q8N7, E9QAR1
      Related
      ENSMUSP00000108047.2, ENSMUST00000112428.8
      Conserved Domains (4) summary
      COG5048
      Location:285 → 426
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:288 → 310
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:330 → 357
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001347452.1 → NP_001334381.1  zinc finger protein 384 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134529, AC164563
      Consensus CDS
      CCDS90119.1
      UniProtKB/TrEMBL
      A0AA74KTG5, E9QAR4
      Conserved Domains (2) summary
      COG5048
      Location:209 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001372420.1 → NP_001359349.1  zinc finger protein 384 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC134529, AC164563
      UniProtKB/TrEMBL
      Q6P3F1
      Conserved Domains (2) summary
      COG5048
      Location:285 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351 → 371
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001372422.1 → NP_001359351.1  zinc finger protein 384 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC134529, AC164563
      Consensus CDS
      CCDS39631.1
      UniProtKB/TrEMBL
      E9Q1A5, Q6P3F1
      Related
      ENSMUSP00000108046.2, ENSMUST00000112427.8
      Conserved Domains (2) summary
      COG5048
      Location:209 → 409
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:320 → 340
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001372424.1 → NP_001359353.1  zinc finger protein 384 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC134529, AC164563
      Consensus CDS
      CCDS39631.1
      UniProtKB/TrEMBL
      E9Q1A5, Q6P3F1
      Conserved Domains (2) summary
      COG5048
      Location:209 → 409
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:320 → 340
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_175557.5 → NP_780766.3  zinc finger protein 384 isoform 1

      See identical proteins and their annotated locations for NP_780766.3

      Status: VALIDATED

      Source sequence(s)
      AC134529, AC164563, BB662626, BY261721, BY595967
      Consensus CDS
      CCDS39631.1
      UniProtKB/TrEMBL
      E9Q1A5, Q6P3F1
      Related
      ENSMUSP00000081296.6, ENSMUST00000084275.12
      Conserved Domains (2) summary
      COG5048
      Location:209 → 409
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:320 → 340
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      124985980..125014833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506201.3 → XP_006506264.1  zinc finger protein 384 isoform X1

      See identical proteins and their annotated locations for XP_006506264.1

      UniProtKB/TrEMBL
      Q6P3F1
      Conserved Domains (2) summary
      COG5048
      Location:285 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351 → 371
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006506204.4 → XP_006506267.1  zinc finger protein 384 isoform X6

      UniProtKB/TrEMBL
      A0AA74KTG5, E9QAR4
      Conserved Domains (2) summary
      COG5048
      Location:209 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_036166185.1 → XP_036022078.1  zinc finger protein 384 isoform X6

      UniProtKB/TrEMBL
      A0AA74KTG5, E9QAR4
      Conserved Domains (2) summary
      COG5048
      Location:209 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_036166189.1 → XP_036022082.1  zinc finger protein 384 isoform X9

      Conserved Domains (2) summary
      COG5048
      Location:64 → 264
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175 → 195
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_036166186.1 → XP_036022079.1  zinc finger protein 384 isoform X7

      UniProtKB/TrEMBL
      D3YX49
      Related
      ENSMUSP00000086354.3, ENSMUST00000054553.11
      Conserved Domains (4) summary
      COG5048
      Location:193 → 379
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:243 → 263
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:241 → 263
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:283 → 310
      zf-H2C2_2; Zinc-finger double domain

    6. XM_036166187.1 → XP_036022080.1  zinc finger protein 384 isoform X9

      Conserved Domains (2) summary
      COG5048
      Location:64 → 264
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175 → 195
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_030255423.1 → XP_030111283.1  zinc finger protein 384 isoform X8

      Conserved Domains (2) summary
      COG5048
      Location:140 → 295
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:206 → 226
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_036166190.1 → XP_036022083.1  zinc finger protein 384 isoform X10

      Conserved Domains (2) summary
      COG5048
      Location:140 → 281
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:145 → 165
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_036166191.1 → XP_036022084.1  zinc finger protein 384 isoform X11

      Conserved Domains (2) summary
      COG5048
      Location:64 → 250
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. XM_030255424.1 → XP_030111284.1  zinc finger protein 384 isoform X12

      Conserved Domains (3) summary
      COG5048
      Location:22 → 177
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:138 → 190
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:88 → 108
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. XM_006506202.3 → XP_006506265.1  zinc finger protein 384 isoform X2

      UniProtKB/TrEMBL
      Q6P3F1
      Conserved Domains (2) summary
      COG5048
      Location:269 → 424
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:335 → 355
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. XM_036166183.1 → XP_036022076.1  zinc finger protein 384 isoform X5

      UniProtKB/TrEMBL
      A0AA74KTG5
      Conserved Domains (4) summary
      COG5048
      Location:269 → 410
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:274 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:272 → 294
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:314 → 341
      zf-H2C2_2; Zinc-finger double domain

    13. XM_030255421.1 → XP_030111281.1  zinc finger protein 384 isoform X3

      UniProtKB/TrEMBL
      E9QAR6, Q6P3F1
      Related
      ENSMUSP00000108043.2, ENSMUST00000112424.2
      Conserved Domains (2) summary
      COG5048
      Location:193 → 393
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:304 → 324
      ZF_C2H2; C2H2 Zn finger [structural motif]

    14. XM_006506205.5 → XP_006506268.1  zinc finger protein 384 isoform X8

      Conserved Domains (2) summary
      COG5048
      Location:140 → 295
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:206 → 226
      ZF_C2H2; C2H2 Zn finger [structural motif]

    15. XM_036166188.1 → XP_036022081.1  zinc finger protein 384 isoform X9

      Conserved Domains (2) summary
      COG5048
      Location:64 → 264
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175 → 195
      ZF_C2H2; C2H2 Zn finger [structural motif]

    16. XM_036166192.1 → XP_036022085.1  zinc finger protein 384 isoform X11

      Conserved Domains (2) summary
      COG5048
      Location:64 → 250
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]

    17. XM_030255425.2 → XP_030111285.1  zinc finger protein 384 isoform X12

      Conserved Domains (3) summary
      COG5048
      Location:22 → 177
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:138 → 190
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:88 → 108
      ZF_C2H2; C2H2 Zn finger [structural motif]

    18. XM_006506200.5 → XP_006506263.1  zinc finger protein 384 isoform X1

      See identical proteins and their annotated locations for XP_006506263.1

      UniProtKB/TrEMBL
      Q6P3F1
      Conserved Domains (2) summary
      COG5048
      Location:285 → 440
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:351 → 371
      ZF_C2H2; C2H2 Zn finger [structural motif]

    19. XM_036166182.1 → XP_036022075.1  zinc finger protein 384 isoform X4

      UniProtKB/TrEMBL
      A0AA74KTG5, E9Q8N7, E9QAR1
      Related
      ENSMUSP00000037986.11, ENSMUST00000046064.17
      Conserved Domains (4) summary
      COG5048
      Location:285 → 426
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:290 → 310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:288 → 310
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:330 → 357
      zf-H2C2_2; Zinc-finger double domain

    20. XM_036166193.1 → XP_036022086.1  zinc finger protein 384 isoform X12

      Conserved Domains (3) summary
      COG5048
      Location:22 → 177
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:138 → 190
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:88 → 108
      ZF_C2H2; C2H2 Zn finger [structural motif]

    21. XM_036166184.1 → XP_036022077.1  zinc finger protein 384 isoform X6

      UniProtKB/TrEMBL
      A0AA74KTG5, E9QAR4
      Related
      ENSMUSP00000108044.2, ENSMUST00000112425.8
      Conserved Domains (2) summary
      COG5048
      Location:209 → 395
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:259 → 279
      ZF_C2H2; C2H2 Zn finger [structural motif]

    22. XM_030255419.2 → XP_030111279.1  zinc finger protein 384 isoform X2

      UniProtKB/TrEMBL
      Q6P3F1
      Conserved Domains (2) summary
      COG5048
      Location:269 → 424
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:335 → 355
      ZF_C2H2; C2H2 Zn finger [structural motif]

    23. XM_030255422.2 → XP_030111282.1  zinc finger protein 384 isoform X3

      UniProtKB/TrEMBL
      E9QAR6, Q6P3F1
      Conserved Domains (2) summary
      COG5048
      Location:193 → 393
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:304 → 324
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
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