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    Exoc6b exocyst complex component 6B [ Mus musculus (house mouse) ]

    Gene ID: 75914, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Exoc6bprovided by MGI
    Official Full Name
    exocyst complex component 6Bprovided by MGI
    Primary source
    MGI:MGI:1923164
    See related
    Ensembl:ENSMUSG00000033769 AllianceGenome:MGI:1923164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sec15b; Sec15l2; mKIAA0919; 4930569O18Rik; G430127E12Rik
    Summary
    Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to be part of exocyst. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 3. Orthologous to human EXOC6B (exocyst complex component 6B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 7.4), cortex adult (RPKM 6.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Exoc6b in Genome Data Viewer
    Location:
    6 C3; 6 36.55 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (84595468..85046524, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (84618486..85070258, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930504D19 gene Neighboring gene STARR-seq mESC enhancer starr_16484 Neighboring gene STARR-seq mESC enhancer starr_16485 Neighboring gene cytochrome P450, family 26, subfamily b, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_16486 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_16489 Neighboring gene STARR-positive B cell enhancer mm9_chr6:84987737-84988037 Neighboring gene STARR-seq mESC enhancer starr_16492 Neighboring gene predicted gene, 57764 Neighboring gene STARR-seq mESC enhancer starr_16493 Neighboring gene nucleoplasmin 3, pseudogene 1 Neighboring gene predicted gene, 52864 Neighboring gene predicted gene 5878

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. Nishiguchi S, et al. J Biochem, 1996 Apr. PMID 8743579
    2. Exorcising the exocyst complex. Heider MR, et al. Traffic, 2012 Jul. PMID 22420621, Free PMC Article
    3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0919

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane fission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle docking involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle tethering involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    exocyst complex component 6B
    Names
    SEC15-like 2
    SEC15-like protein 2
    exocyst complex component Sec15B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177077.2 → NP_796051.2  exocyst complex component 6B

      See identical proteins and their annotated locations for NP_796051.2

      Status: VALIDATED

      Source sequence(s)
      AC153373, AC153606, AC153994, AC155289, AC155331
      Consensus CDS
      CCDS51824.1
      UniProtKB/Swiss-Prot
      A6H5Z3, Q3UN15
      Related
      ENSMUSP00000125312.2, ENSMUST00000160197.6
      Conserved Domains (1) summary
      pfam04091
      Location:464 → 770
      Sec15; Exocyst complex subunit Sec15-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      84595468..85046524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506729.3 → XP_006506792.1  exocyst complex component 6B isoform X6

      Conserved Domains (1) summary
      pfam04091
      Location:352 → 658
      Sec15; Exocyst complex subunit Sec15-like

    2. XM_006506728.4 → XP_006506791.1  exocyst complex component 6B isoform X2

      Conserved Domains (1) summary
      pfam04091
      Location:464 → 769
      Sec15; Exocyst complex subunit Sec15-like

    3. XM_036152390.1 → XP_036008283.1  exocyst complex component 6B isoform X1

      Conserved Domains (2) summary
      pfam05483
      Location:2 → 266
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      pfam04091
      Location:464 → 770
      Sec15; Exocyst complex subunit Sec15-like

    4. XM_036152391.1 → XP_036008284.1  exocyst complex component 6B isoform X3

      Conserved Domains (2) summary
      pfam05483
      Location:2 → 266
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      pfam04091
      Location:464 → 769
      Sec15; Exocyst complex subunit Sec15-like

    5. XM_036152393.1 → XP_036008286.1  exocyst complex component 6B isoform X5

      Conserved Domains (1) summary
      pfam04091
      Location:352 → 658
      Sec15; Exocyst complex subunit Sec15-like

    6. XM_036152392.1 → XP_036008285.1  exocyst complex component 6B isoform X4

      Conserved Domains (2) summary
      pfam05483
      Location:2 → 266
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      pfam04091
      Location:464 → 732
      Sec15; Exocyst complex subunit Sec15-like

    7. XM_017321822.3 → XP_017177311.1  exocyst complex component 6B isoform X7

      Conserved Domains (1) summary
      pfam04091
      Location:464 → 667
      Sec15; Exocyst complex subunit Sec15-like

    8. XM_011241500.3 → XP_011239802.1  exocyst complex component 6B isoform X8

      Conserved Domains (1) summary
      pfam04091
      Location:464 → 662
      Sec15; Exocyst complex subunit Sec15-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6H5Z3.1 GenPept UniProtKB/Swiss-Prot:A6H5Z3

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