Zfp819 zinc finger protein 819 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp819provided by MGI
Official Full Name: zinc finger protein 819provided by MGI
Primary source: MGI:MGI:1921650
See related: Ensembl:ENSMUSG00000055102 AllianceGenome:MGI:1921650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930427I11Rik; 4933405K07Rik
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of DNA-templated transcription and positive regulation of apoptotic process. Located in nucleus. Is expressed in brain; early conceptus; eye; and inner ear. Orthologous to human ZNF175 (zinc finger protein 175). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 2.3) and CNS E11.5 (RPKM 0.1) See more
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Genomic context

Location:: 7 B3; 7 28.25 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43256559..43267703)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43607135..43618279)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819.
Title: A satellite DNA array barcodes chromosome 7 and regulates totipotency via ZFP819.
Results show that Zfp819 is expressed exclusively in spermatogenic cells. Its overexpression suppressed cell proliferation and induced apoptosis.
Title: Identification and characterization of reproductive KRAB-ZF genes in mice.
Zfp819 is a novel pluripotency-related factor and unveiled its function in genomic integrity maintenance mechanisms of mouse embryonic stem cells.
Title: Zfp819, a novel KRAB-zinc finger protein, interacts with KAP1 and functions in genomic integrity maintenance of mouse embryonic stem cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 819

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355131.1 → NP_001342060.1 zinc finger protein 819 isoform 2

Status: VALIDATED

Source sequence(s)

AC154108

Consensus CDS

CCDS90218.1

UniProtKB/TrEMBL

E9Q5X9

Related

ENSMUSP00000113867.2, ENSMUST00000120935.2

Conserved Domains (3) summary

COG5048
Location:217 → 455

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:366 → 386

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:463 → 487

zf-H2C2_2; Zinc-finger double domain
NM_028913.3 → NP_083189.2 zinc finger protein 819 isoform 1

See identical proteins and their annotated locations for NP_083189.2

Status: VALIDATED

Source sequence(s)

AC154108, AK016669

Consensus CDS

CCDS21176.1

UniProtKB/TrEMBL

Q80V81

Related

ENSMUSP00000032661.7, ENSMUST00000032661.14

Conserved Domains (4) summary

smart00349
Location:27 → 81

KRAB; krueppel associated box

COG5048
Location:293 → 531

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:442 → 462

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:539 → 563

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

43256559..43267703

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312353.2 → XP_017167842.1 zinc finger protein 819 isoform X1

UniProtKB/TrEMBL

Q80V81

Conserved Domains (4) summary

smart00349
Location:27 → 81

KRAB; krueppel associated box

COG5048
Location:293 → 531

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:442 → 462

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:539 → 563

zf-H2C2_2; Zinc-finger double domain