Klk13 kallikrein related-peptidase 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klk13provided by MGI
Official Full Name: kallikrein related-peptidase 13provided by MGI
Primary source: MGI:MGI:3615275
See related: Ensembl:ENSMUSG00000054046 AllianceGenome:MGI:3615275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mGk-13; Egfbp-2
Summary: Kallikreins are serine proteases encoded by a cluster of highly related genes on chromosome 7. When genomic sequence became available, it was possible to clarify the gene-to-sequence relationship for this family. Until January, 2006, NM_010115 was called kallikrein 13. After that time, NM_001039042 was called Klk13 and NM_010115 was called Klk1b26. [provided by RefSeq, Jul 2008]
Expression: Biased expression in stomach adult (RPKM 14.7) and lung adult (RPKM 5.4) See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.26 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43361991..43377288)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (43712567..43727864)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

kallikrein mK13 is a plausible candidate for the processing enzyme for pro-IL-1beta in the submandibular gland of mice
Title: Tissue kallikrein mK13 is a candidate processing enzyme for the precursor of interleukin-1beta in the submandibular gland of mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein processing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kallikrein-13

Names: kallikrein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039042.2 → NP_001034131.2 kallikrein-13 precursor

See identical proteins and their annotated locations for NP_001034131.2

Status: VALIDATED

Source sequence(s)

BC063763

Consensus CDS

CCDS39933.1

UniProtKB/TrEMBL

Q8CGR6

Related

ENSMUSP00000065308.7, ENSMUST00000066834.8

Conserved Domains (1) summary

cd00190
Location:39 → 262

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

43361991..43377288

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006541056.4 → XP_006541119.1 kallikrein-13 isoform X1

See identical proteins and their annotated locations for XP_006541119.1

UniProtKB/TrEMBL

Q8CGR6

Conserved Domains (1) summary

cd00190
Location:39 → 262

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006541055.4 → XP_006541118.1 kallikrein-13 isoform X1

See identical proteins and their annotated locations for XP_006541118.1

UniProtKB/TrEMBL

Q8CGR6

Conserved Domains (1) summary

cd00190
Location:39 → 262

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_011250887.3 → XP_011249189.1 kallikrein-13 isoform X2

Conserved Domains (1) summary

cd00190
Location:39 → 168

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_017322442.1 → XP_017177931.1 kallikrein-13 isoform X3

Conserved Domains (1) summary

smart00020
Location:18 → 156

Tryp_SPc; Trypsin-like serine protease