Furin furin, paired basic amino acid cleaving enzyme [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Furinprovided by MGI
Official Full Name: furin, paired basic amino acid cleaving enzymeprovided by MGI
Primary source: MGI:MGI:97513
See related: Ensembl:ENSMUSG00000030530 AllianceGenome:MGI:97513
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fur; PACE; SPC1; Pcsk3; 9130404I01Rik
Summary: This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression: Broad expression in stomach adult (RPKM 243.5), adrenal adult (RPKM 89.1) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D2; 7 45.65 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (80038942..80055188, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (80389194..80405441, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing.
Title: Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing.
The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.
Title: The Furin Protease Dependence and Antiviral GBP2 Sensitivity of Murine Leukemia Virus Infection Are Determined by the Amino Acid Sequence at the Envelope Glycoprotein Cleavage Site.
Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury.
Title: Furin Regulates the Alveolarization of Neonatal Lungs in a Mouse Model of Hyperoxic Lung Injury.
FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice.
Title: FURIN regulates cytotoxic T-lymphocyte effector function and memory cell transition in mice.
FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy.
Title: FURIN suppresses the progression of atherosclerosis by promoting macrophage autophagy.
Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice.
Title: Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice.
Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner.
Title: Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner.
In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23.
Title: In Vivo Analysis of the Contribution of Proprotein Convertases to the Processing of FGF23.
Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells.
Title: Identification of Novel Genetic Regulatory Region for Proprotein Convertase FURIN and Interferon Gamma in T Cells.
Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic beta Cells of Mice.
Title: Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic β Cells of Mice.

Submit: New GeneRIF Correction See all GeneRIFs (51)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Furin (e-PCR), detects polymorphism
- UniSTS:532487

Pcsk3 (e-PCR), detects polymorphism
- UniSTS:144143

PMC156147P3 (e-PCR)
- UniSTS:271380

RH94589 (e-PCR)
- UniSTS:119837

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

FURIN (e-PCR)
- UniSTS:265098

D7Mit90 (e-PCR), detects polymorphism
- UniSTS:116726

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables heparan sulfate binding	ISO Inferred from Sequence Orthology more info
enables heparan sulfate binding	ISS Inferred from Sequence or Structural Similarity more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nerve growth factor binding	IEA Inferred from Electronic Annotation more info
enables nerve growth factor binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables peptide binding	IEA Inferred from Electronic Annotation more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	EXP Inferred from Experiment more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables serine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables serine-type endopeptidase activity	TAS Traceable Author Statement more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in blastocyst formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytokine precursor processing	ISO Inferred from Sequence Orthology more info
involved_in cytokine precursor processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in dibasic protein processing	IEA Inferred from Electronic Annotation more info
involved_in dibasic protein processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta1 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transforming growth factor beta1 production	ISO Inferred from Sequence Orthology more info
involved_in nerve growth factor production	IEA Inferred from Electronic Annotation more info
involved_in nerve growth factor production	ISO Inferred from Sequence Orthology more info
involved_in peptide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in peptide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in peptide hormone processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide hormone processing	IEA Inferred from Electronic Annotation more info
involved_in peptide hormone processing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein maturation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within protein processing	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein processing	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cholesterol transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in secretion by cell	IEA Inferred from Electronic Annotation more info
involved_in secretion by cell	ISO Inferred from Sequence Orthology more info
involved_in signal peptide processing	IDA Inferred from Direct Assay more info	PubMed
involved_in signal peptide processing	ISO Inferred from Sequence Orthology more info	PubMed
involved_in viral life cycle	IEA Inferred from Electronic Annotation more info
involved_in zymogen activation	IEA Inferred from Electronic Annotation more info
involved_in zymogen activation	ISO Inferred from Sequence Orthology more info
involved_in zymogen inhibition	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi cisterna	ISO Inferred from Sequence Orthology more info
is_active_in Golgi lumen	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in early endosome	TAS Traceable Author Statement more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network transport vesicle	ISO Inferred from Sequence Orthology more info	PubMed
located_in trans-Golgi network transport vesicle membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: furin

Names: dibasic-processing enzyme; paired basic amino acid residue cleaving enzyme; prohormone convertase 3; proprotein convertase subtilisin/kexin type 3; subtilisin pro-protein processing enzyme

NP_001074923.1

EC 3.4.21.75

NP_035176.1

EC 3.4.21.75

XP_011249120.1

EC 3.4.21.75

XP_011249121.1

EC 3.4.21.75

XP_011249122.1

EC 3.4.21.75

XP_011249123.1

EC 3.4.21.75

XP_011249124.1

EC 3.4.21.75

XP_011249125.1

EC 3.4.21.75

XP_030098069.1

EC 3.4.21.75

XP_030098070.1

EC 3.4.21.75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081454.2 → NP_001074923.1 furin preproprotein

See identical proteins and their annotated locations for NP_001074923.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC136740

Consensus CDS

CCDS21397.1

UniProtKB/Swiss-Prot

P23188, Q6GTN6

Related

ENSMUSP00000102985.4, ENSMUST00000107362.10

Conserved Domains (4) summary

cd04059
Location:113 → 402

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:638 → 675

FU; Furin-like repeats

pfam01483
Location:484 → 570

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:33 → 107

S8_pro-domain; Peptidase S8 pro-domain
NM_011046.3 → NP_035176.1 furin preproprotein

See identical proteins and their annotated locations for NP_035176.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC136740

Consensus CDS

CCDS21397.1

UniProtKB/Swiss-Prot

P23188, Q6GTN6

Related

ENSMUSP00000113370.2, ENSMUST00000122232.8

Conserved Domains (4) summary

cd04059
Location:113 → 402

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:638 → 675

FU; Furin-like repeats

pfam01483
Location:484 → 570

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:33 → 107

S8_pro-domain; Peptidase S8 pro-domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

80038942..80055188 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250821.3 → XP_011249123.1 furin isoform X1

See identical proteins and their annotated locations for XP_011249123.1

Conserved Domains (4) summary

cd04059
Location:113 → 412

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:648 → 685

FU; Furin-like repeats

pfam01483
Location:494 → 580

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:33 → 107

S8_pro-domain; Peptidase S8 pro-domain
XM_011250822.3 → XP_011249124.1 furin isoform X1

See identical proteins and their annotated locations for XP_011249124.1

Conserved Domains (4) summary

cd04059
Location:113 → 412

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:648 → 685

FU; Furin-like repeats

pfam01483
Location:494 → 580

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:33 → 107

S8_pro-domain; Peptidase S8 pro-domain
XM_011250819.4 → XP_011249121.1 furin isoform X1

See identical proteins and their annotated locations for XP_011249121.1

Conserved Domains (4) summary

cd04059
Location:113 → 412

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:648 → 685

FU; Furin-like repeats

pfam01483
Location:494 → 580

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:33 → 107

S8_pro-domain; Peptidase S8 pro-domain
XM_011250818.2 → XP_011249120.1 furin isoform X1

See identical proteins and their annotated locations for XP_011249120.1

Conserved Domains (4) summary

cd04059
Location:113 → 412

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:648 → 685

FU; Furin-like repeats

pfam01483
Location:494 → 580

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:33 → 107

S8_pro-domain; Peptidase S8 pro-domain
XM_030242209.2 → XP_030098069.1 furin isoform X2

UniProtKB/Swiss-Prot

P23188, Q6GTN6

Conserved Domains (4) summary

cd04059
Location:113 → 402

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:638 → 675

FU; Furin-like repeats

pfam01483
Location:484 → 570

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:33 → 107

S8_pro-domain; Peptidase S8 pro-domain
XM_011250820.4 → XP_011249122.1 furin isoform X1

See identical proteins and their annotated locations for XP_011249122.1

Conserved Domains (4) summary

cd04059
Location:113 → 412

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:648 → 685

FU; Furin-like repeats

pfam01483
Location:494 → 580

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:33 → 107

S8_pro-domain; Peptidase S8 pro-domain
XM_030242210.2 → XP_030098070.1 furin isoform X2

UniProtKB/Swiss-Prot

P23188, Q6GTN6

Conserved Domains (4) summary

cd04059
Location:113 → 402

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:638 → 675

FU; Furin-like repeats

pfam01483
Location:484 → 570

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:33 → 107

S8_pro-domain; Peptidase S8 pro-domain
XM_011250823.1 → XP_011249125.1 furin isoform X1

See identical proteins and their annotated locations for XP_011249125.1

Conserved Domains (4) summary

cd04059
Location:113 → 412

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

smart00261
Location:648 → 685

FU; Furin-like repeats

pfam01483
Location:494 → 580

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:33 → 107

S8_pro-domain; Peptidase S8 pro-domain