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    ZNF23 zinc finger protein 23 [ Homo sapiens (human) ]

    Gene ID: 7571, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZNF23provided by HGNC
    Official Full Name
    zinc finger protein 23provided by HGNC
    Primary source
    HGNC:HGNC:13023
    See related
    Ensembl:ENSG00000167377 MIM:194527; AllianceGenome:HGNC:13023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX16; ZNF359; ZNF612; Zfp612
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 6.2), brain (RPKM 4.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF23 in Genome Data Viewer
    Location:
    16q22.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (71447597..71462247, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (77264821..77279471, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (71481500..71496150, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11072 Neighboring gene tRNA-Met (anticodon CAT) 2-1 Neighboring gene TLE family member 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11073 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11074 Neighboring gene uncharacterized LOC124903709 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:71507841-71509040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11075 Neighboring gene zinc finger protein 19 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:71517771-71518680

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF23 Suppresses Cutaneous Melanoma Cell Malignancy via Mitochondria-Dependent Pathway. Zhang X, et al. Cell Physiol Biochem, 2017. PMID 28848158
    2. Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression. Huang C, et al. Exp Cell Res, 2007 Jan 15. PMID 17137575
    3. ZNF23 induces apoptosis in human ovarian cancer cells. Huang C, et al. Cancer Lett, 2008 Aug 8. PMID 18384939
    4. Expression of zinc finger 23 gene in human hepatocellular carcinoma. Shi Y, et al. Anticancer Res, 2011 Oct. PMID 21965783
    5. Nucleolar small molecule RNA SNORA75 promotes endometrial receptivity by regulating the function of miR-146a-3p and ZNF23. Wei P, et al. Aging (Albany NY), 2021 May 24. PMID 34030136, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing of miR-1246 Induces Cell Cycle Arrest and Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells by Promoting ZNF23 Transcription.
      Title: Silencing of miR-1246 Induces Cell Cycle Arrest and Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells by Promoting ZNF23 Transcription.
    2. Nucleolar small molecule RNA SNORA75 promotes endometrial receptivity by regulating the function of miR-146a-3p and ZNF23.
      Title: Nucleolar small molecule RNA SNORA75 promotes endometrial receptivity by regulating the function of miR-146a-3p and ZNF23.
    3. Ectopic expression of ZNF23 induced cell apoptosis by activation of caspase-3, p27, p53 expression and down-regulation of Bcl-2 through mitochondria-dependent pathway.
      Title: ZNF23 Suppresses Cutaneous Melanoma Cell Malignancy via Mitochondria-Dependent Pathway.
    4. ZNF23 gene could play an important role in the development of hepatocellular carcinoma.
      Title: Expression of zinc finger 23 gene in human hepatocellular carcinoma.
    5. ZNF23 induced apoptosis partially via down-regulation of Bcl-XL.
      Title: ZNF23 induces apoptosis in human ovarian cancer cells.
    6. ZNF23 is a new member of KRAB-ZNF superfamily with growth-inhibitory ability and its downregulation may contribute to carcinogenesis
      Title: Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression.
    7. Characterization of ZNF359 and its role in human development
      Title: Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: ZNF19

    Homology

    Clone Names

    • MGC57283

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 23
    Names
    kruppel-like zinc finger factor X31
    zinc finger protein 23 (KOX 16)
    zinc finger protein 32
    zinc finger protein 359
    zinc finger protein 612

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304492.2 → NP_001291421.1  zinc finger protein 23 isoform a

      See identical proteins and their annotated locations for NP_001291421.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2), as well as variants 1, 5, and 6, encodes isoform a.
      Source sequence(s)
      AK091039, AL080123
      Consensus CDS
      CCDS10900.1
      UniProtKB/Swiss-Prot
      P17027, Q8NDP5, Q96IT3, Q9UG42
      Related
      ENSP00000349796.4, ENST00000357254.8
      Conserved Domains (3) summary
      COG5048
      Location:186 → 606
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:338 → 358
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    2. NM_001304493.2 → NP_001291422.1  zinc finger protein 23 isoform b

      See identical proteins and their annotated locations for NP_001291422.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 4-12, encodes isoform b.
      Source sequence(s)
      AC010547, AL080123, BC048974, DB160047
      Consensus CDS
      CCDS76895.1
      UniProtKB/Swiss-Prot
      P17027
      Conserved Domains (2) summary
      COG5048
      Location:128 → 548
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280 → 300
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001304494.2 → NP_001291423.1  zinc finger protein 23 isoform b

      See identical proteins and their annotated locations for NP_001291423.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 3 and 5-12, encodes isoform b.
      Source sequence(s)
      AK297130, AL080123, DB160047
      Consensus CDS
      CCDS76895.1
      UniProtKB/Swiss-Prot
      P17027
      UniProtKB/TrEMBL
      B4DLS2
      Related
      ENSP00000462429.1, ENST00000564528.1
      Conserved Domains (2) summary
      COG5048
      Location:128 → 548
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280 → 300
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001381965.1 → NP_001368894.1  zinc finger protein 23 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 2, and 6, encodes isoform a.
      Source sequence(s)
      AC010547
      Consensus CDS
      CCDS10900.1
      UniProtKB/Swiss-Prot
      P17027, Q8NDP5, Q96IT3, Q9UG42
      Conserved Domains (3) summary
      COG5048
      Location:186 → 606
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:338 → 358
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    5. NM_001381966.1 → NP_001368895.1  zinc finger protein 23 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 2, and 5, encodes isoform a.
      Source sequence(s)
      AC010547
      Consensus CDS
      CCDS10900.1
      UniProtKB/Swiss-Prot
      P17027, Q8NDP5, Q96IT3, Q9UG42
      Conserved Domains (3) summary
      COG5048
      Location:186 → 606
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:338 → 358
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    6. NM_001381967.1 → NP_001368896.1  zinc finger protein 23 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variants 3, 4, and 8-12, encodes isoform b.
      Source sequence(s)
      AC010547
      Consensus CDS
      CCDS76895.1
      Conserved Domains (2) summary
      COG5048
      Location:128 → 548
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280 → 300
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001381968.1 → NP_001368897.1  zinc finger protein 23 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variants 3, 4, 7, and 9-12, encodes isoform b.
      Source sequence(s)
      AC010547
      Consensus CDS
      CCDS76895.1
      Conserved Domains (2) summary
      COG5048
      Location:128 → 548
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280 → 300
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001381969.1 → NP_001368898.1  zinc finger protein 23 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variants 3, 4, 7, 8, and 10-12, encodes isoform b.
      Source sequence(s)
      AC010547
      Consensus CDS
      CCDS76895.1
      Conserved Domains (2) summary
      COG5048
      Location:128 → 548
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280 → 300
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001381970.1 → NP_001368899.1  zinc finger protein 23 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variants 3, 4, 7-9, 11, and 12, encodes isoform b.
      Source sequence(s)
      AC010547
      Consensus CDS
      CCDS76895.1
      Conserved Domains (2) summary
      COG5048
      Location:128 → 548
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280 → 300
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. NM_001381971.1 → NP_001368900.1  zinc finger protein 23 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variants 3, 4, 7-10, and 12, encodes isoform b.
      Source sequence(s)
      AC010547
      Consensus CDS
      CCDS76895.1
      Conserved Domains (2) summary
      COG5048
      Location:128 → 548
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280 → 300
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. NM_001381972.1 → NP_001368901.1  zinc finger protein 23 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variants 3, 4, and 7-11, encodes isoform b.
      Source sequence(s)
      AC010547
      Consensus CDS
      CCDS76895.1
      Conserved Domains (2) summary
      COG5048
      Location:128 → 548
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:280 → 300
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. NM_001381973.1 → NP_001368902.1  zinc finger protein 23 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variant 14, encodes isoform c.
      Source sequence(s)
      AC010547
      Conserved Domains (3) summary
      smart00349
      Location:10 → 69
      KRAB; krueppel associated box
      COG5048
      Location:225 → 645
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]

    13. NM_001381974.1 → NP_001368903.1  zinc finger protein 23 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variant 13, encodes isoform c.
      Source sequence(s)
      AC010547
      Conserved Domains (3) summary
      smart00349
      Location:10 → 69
      KRAB; krueppel associated box
      COG5048
      Location:225 → 645
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:377 → 397
      ZF_C2H2; C2H2 Zn finger [structural motif]

    14. NM_001381975.1 → NP_001368904.1  zinc finger protein 23 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 16-19, encodes isoform d.
      Source sequence(s)
      AC010547
      Conserved Domains (3) summary
      COG5048
      Location:187 → 607
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:339 → 359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    15. NM_001381976.1 → NP_001368905.1  zinc finger protein 23 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16), as well as variants 15 and 17-19, encodes isoform d.
      Source sequence(s)
      AC010547
      Conserved Domains (3) summary
      COG5048
      Location:187 → 607
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:339 → 359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    16. NM_001381977.1 → NP_001368906.1  zinc finger protein 23 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17), as well as variants 15, 16, 18, and 19, encodes isoform d.
      Source sequence(s)
      AC010547
      Conserved Domains (3) summary
      COG5048
      Location:187 → 607
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:339 → 359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    17. NM_001381978.1 → NP_001368907.1  zinc finger protein 23 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18), as well as variants 15-17 and 19, encodes isoform d.
      Source sequence(s)
      AC010547
      Conserved Domains (3) summary
      COG5048
      Location:187 → 607
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:339 → 359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    18. NM_001381979.1 → NP_001368908.1  zinc finger protein 23 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19), as well as variants 15-18, encodes isoform d.
      Source sequence(s)
      AC010547
      Conserved Domains (3) summary
      COG5048
      Location:187 → 607
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:339 → 359
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    19. NM_001381980.1 → NP_001368909.1  zinc finger protein 23 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC010547
      Conserved Domains (3) summary
      smart00349
      Location:10 → 69
      KRAB; krueppel associated box
      COG5048
      Location:224 → 644
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:376 → 396
      ZF_C2H2; C2H2 Zn finger [structural motif]

    20. NM_001381981.1 → NP_001368910.1  zinc finger protein 23 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC010547
      Conserved Domains (3) summary
      COG5048
      Location:190 → 610
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:342 → 362
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    21. NM_001381984.1 → NP_001368913.1  zinc finger protein 23 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22) encodes the longest isoform (g).
      Source sequence(s)
      AC010547
      Consensus CDS
      CCDS92194.1
      UniProtKB/TrEMBL
      A0A3B3ITE4
      Related
      ENSP00000497736.2, ENST00000647773.2
      Conserved Domains (3) summary
      smart00349
      Location:14 → 73
      KRAB; krueppel associated box
      COG5048
      Location:229 → 649
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:381 → 401
      ZF_C2H2; C2H2 Zn finger [structural motif]

    22. NM_145911.3 → NP_666016.1  zinc finger protein 23 isoform a

      See identical proteins and their annotated locations for NP_666016.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variants 2, 5, and 6, encodes isoform a.
      Source sequence(s)
      AC010547, AL080123, BC007256, DA530642
      Consensus CDS
      CCDS10900.1
      UniProtKB/Swiss-Prot
      P17027, Q8NDP5, Q96IT3, Q9UG42
      Related
      ENSP00000377171.2, ENST00000393539.6
      Conserved Domains (3) summary
      COG5048
      Location:186 → 606
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:338 → 358
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl02581
      Location:1 → 31
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      71447597..71462247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      77264821..77279471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17027.3 GenPept UniProtKB/Swiss-Prot:P17027

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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