Klk8 kallikrein related-peptidase 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klk8provided by RGD
Official Full Name: kallikrein related-peptidase 8provided by RGD
Primary source: RGD:1305998
See related: EnsemblRapid:ENSRNOG00000018580 AllianceGenome:RGD:1305998
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Klnh; bsp1
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including keratinocyte proliferation; memory; and neuron projection morphogenesis. Predicted to act upstream of or within synapse organization. Predicted to be located in cytoplasm. Predicted to be part of serine protease inhibitor complex. Predicted to be active in extracellular space and secretory granule. Orthologous to human KLK8 (kallikrein related peptidase 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 8.8), Brain (RPKM 4.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (103388352..103395195)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (94251803..94258646)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (99735168..99742011)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kallikrein-related peptidase-8 (KLK8) aggravated hypoxia-induced right ventricular hypertrophy by targeting P38 MAPK/P53 signaling pathway.
Title: Kallikrein-related peptidase-8 (KLK8) aggravated hypoxia-induced right ventricular hypertrophy by targeting P38 MAPK/P53 signaling pathway.
KLK8 protects the heart against ischemia/reperfusion-induced cardiac injury.
Title: Tissue kallikrein-related peptidase8 protects rat heart against acute ischemia reperfusion injury.
our data suggest that KLK8 may promote cardiomyocyte hypertrophy through EGF signaling- and PARs-dependent but a kinin receptor-independent pathway. It is implied that different KLK family members can subtly regulate cardiac function and remodeling.
Title: Kallikrein-related peptidase 8 is expressed in myocardium and induces cardiac hypertrophy.
KLK8 and KLK14 can signal differentially via the PARs to affect tissue function
Title: Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14.
Klk8 rat gene was expressed at high levels in the submandibular glands of transgenic mice.
Title: The transcriptional regulatory strategy of the rat tissue kallikrein gene family.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in memory	IEA Inferred from Electronic Annotation more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
part_of serine protease inhibitor complex	IEA Inferred from Electronic Annotation more info
part_of serine protease inhibitor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kallikrein-8

Names: NP; brain serine protease 1; kallikrein 8 (neuropsin/ovasin); kallikrein h; neuropsin; serine protease 19

NP_001100979.1

EC 3.4.21.118

XP_063117837.1

EC 3.4.21.118

XP_063117840.1

EC 3.4.21.118

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107509.1 → NP_001100979.1 kallikrein-8 precursor

See identical proteins and their annotated locations for NP_001100979.1

Status: PROVISIONAL

Source sequence(s)

CH473979

UniProtKB/Swiss-Prot

O88780

UniProtKB/TrEMBL

A6JAK0, G3V8E9

Related

ENSRNOP00000025174.2, ENSRNOT00000025174.6

Conserved Domains (1) summary

smart00020
Location:32 → 252

Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

103388352..103395195

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261767.1 → XP_063117837.1 kallikrein-8 isoform X1

UniProtKB/Swiss-Prot

O88780

UniProtKB/TrEMBL

A6JAK0, G3V8E9
XM_063261770.1 → XP_063117840.1 kallikrein-8 isoform X1

UniProtKB/Swiss-Prot

O88780

UniProtKB/TrEMBL

A6JAK0, G3V8E9