Klk4 kallikrein-related peptidase 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klk4provided by RGD
Official Full Name: kallikrein-related peptidase 4provided by RGD
Primary source: RGD:1303228
See related: EnsemblRapid:ENSRNOG00000018864 AllianceGenome:RGD:1303228
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Emsp1; Klnb1
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in amelogenesis; extracellular matrix disassembly; and protein maturation. Predicted to act upstream of or within protein catabolic process. Predicted to be active in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A1 and prostate cancer. Orthologous to human KLK4 (kallikrein related peptidase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (103480731..103485963)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (94344195..94349425)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (99828944..99834642)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type peptidase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in amelogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within amelogenesis	ISO Inferred from Sequence Orthology more info
involved_in amelogenesis	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix disassembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: kallikrein-4

Names: Enamel matrix serine proteinase 1; kallikrein 4 (prostase, enamel matrix, prostate); kallikrein b1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004101.2 → NP_001004101.1 kallikrein-4 precursor

See identical proteins and their annotated locations for NP_001004101.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

F7F4Q8, Q6IE12

Related

ENSRNOP00000025614.4, ENSRNOT00000025614.6

Conserved Domains (1) summary

cd00190
Location:35 → 249

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...