Slc22a21 solute carrier family 22 (organic cation transporter), member 21 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc22a21provided by RGD
Official Full Name: solute carrier family 22 (organic cation transporter), member 21provided by RGD
Primary source: RGD:1561735
See related: EnsemblRapid:ENSRNOG00000069239 AllianceGenome:RGD:1561735
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Octn3
Summary: Predicted to enable carnitine transmembrane transporter activity. Predicted to be involved in carnitine transmembrane transport and monoatomic ion transport. Predicted to act upstream of or within carnitine transport. Predicted to be located in peroxisomal membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 127.6), Testes (RPKM 101.0) and 9 other tissues See more
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Genomic context

Location:: 10q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (38605665..38633376, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (38104114..38133106, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (39296904..39324861, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OCTN3 is densely expressed within the intercalated cell groups of the amygdala.
Title: Organic cation transporter 3 is densely expressed in the intercalated cell groups of the amygdala: anatomical evidence for a stress hormone-sensitive dopamine clearance system.
a physiological role of OCTN3 as peroxisomal membrane transporter.
Title: Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist.
Results demonstrate that mammalian small intestine expresses OCTN3 mRNA along the villus and that OCTN3 protein is located in the basolateral membrane.
Title: OCTN3: A Na+-independent L-carnitine transporter in enterocytes basolateral membrane.

Submit: New GeneRIF Correction

General gene information

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Markers

AU047818 (e-PCR)
- UniSTS:110144

RH131079 (e-PCR)
- UniSTS:214362

D10Mco55 (e-PCR)
- UniSTS:240234

RH133914 (e-PCR)
- UniSTS:217197

NoName (e-PCR)
- UniSTS:547023

Slc22a21 (e-PCR), detects polymorphism
- UniSTS:547023

Homology

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carnitine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables quaternary ammonium group transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in carnitine transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within carnitine transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in quaternary ammonium group transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cartregulin; organic cation/carnitine transporter 2; solute carrier family 22 member 21

Names: solute carrier family 22 member 5; up-regulator of carnitine transporter, OCTN2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

38605665..38633376 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087194.2 → XP_038943122.1 solute carrier family 22 member 21 isoform X2

Conserved Domains (1) summary

TIGR00898
Location:52 → 357

2A0119; cation transport protein
XM_008767743.4 → XP_008765965.1 solute carrier family 22 member 21 isoform X1

See identical proteins and their annotated locations for XP_008765965.1

UniProtKB/TrEMBL

A0A8I6GM55, A6HEF6, A6HEF7

Related

ENSRNOP00000049867.5, ENSRNOT00000041253.6

Conserved Domains (2) summary

cd06174
Location:123 → 513

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:12 → 523

2A0119; cation transport protein
XM_039087195.2 → XP_038943123.1 solute carrier family 22 member 21 isoform X3

Conserved Domains (1) summary

TIGR00898
Location:1 → 347

2A0119; cation transport protein
XM_039087198.2 → XP_038943126.1 organic cation/carnitine transporter 2 isoform X6

Conserved Domains (1) summary

TIGR00898
Location:12 → 317

2A0119; cation transport protein
XM_039087196.2 → XP_038943124.1 solute carrier family 22 member 21 isoform X4

Conserved Domains (1) summary

TIGR00898
Location:12 → 353

2A0119; cation transport protein
XM_039087197.2 → XP_038943125.1 organic cation/carnitine transporter 2 isoform X5

Conserved Domains (1) summary

TIGR00898
Location:12 → 322

2A0119; cation transport protein