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    Radil Rap associating with DIL domain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304299, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Radilprovided by RGD
    Official Full Name
    Rap associating with DIL domainprovided by RGD
    Primary source
    RGD:1306155
    See related
    EnsemblRapid:ENSRNOG00000024456 AllianceGenome:RGD:1306155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306155
    Summary
    Predicted to enable GTPase binding activity. Predicted to be involved in neural crest cell migration and substrate adhesion-dependent cell spreading. Predicted to be part of protein-containing complex. Predicted to be active in microtubule. Orthologous to human RADIL (Rap associating with DIL domain). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 24.6), Testes (RPKM 23.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Radil in Genome Data Viewer
    Location:
    12p11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (17137872..17202021)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (12024395..12088540)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (14092541..14156704)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene monocyte to macrophage differentiation-associated 2 Neighboring gene poly(A) polymerase beta Neighboring gene adaptor related protein complex 5 subunit zeta 1 Neighboring gene forkhead box K1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity. de Kreuk BJ, et al. Elife, 2016 Jan 19. PMID 26780829, Free PMC Article
    2. A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. Smolen GA, et al. Genes Dev, 2007 Sep 1. PMID 17704304, Free PMC Article
    3. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. Ahmed SM, et al. J Cell Biol, 2012 Dec 10. PMID 23209302, Free PMC Article
    4. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-associating and dilute domain-containing protein
    Names
    Rap GTPase interactor
    Ras association and DIL domains

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037218.2 → NP_001032295.2  ras-associating and dilute domain-containing protein

      See identical proteins and their annotated locations for NP_001032295.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6K1Q1, D4A1Z8
      Related
      ENSRNOP00000083450.2, ENSRNOT00000095294.2
      Conserved Domains (4) summary
      cd00992
      Location:970 → 1054
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:411 → 778
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
      pfam00498
      Location:273 → 343
      FHA; FHA domain
      pfam00788
      Location:61 → 164
      RA; Ras association (RalGDS/AF-6) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      17137872..17202021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598319.2 → XP_017453808.1  ras-associating and dilute domain-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWZ1, A6K1Q0, D4A1Z8
      Related
      ENSRNOP00000100419.1, ENSRNOT00000155043.1
      Conserved Domains (4) summary
      cd00992
      Location:999 → 1083
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd15472
      Location:440 → 807
      Myo5p-like_CBD_Rasip1; cargo binding domain of myosin 5-like of Ras-interacting protein 1
      pfam00498
      Location:302 → 372
      FHA; FHA domain
      pfam00788
      Location:90 → 193
      RA; Ras association (RalGDS/AF-6) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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