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    Selplg selectin P ligand [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Selplgprovided by RGD
    Official Full Name
    selectin P ligandprovided by RGD
    Primary source
    RGD:1307971
    See related
    EnsemblRapid:ENSRNOG00000000699 AllianceGenome:RGD:1307971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Psgl1; Selpl
    Summary
    Involved in positive regulation of hepatocyte apoptotic process. Predicted to be located in plasma membrane raft and uropod. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human SELPLG (selectin P ligand). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 260.0), Thymus (RPKM 153.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Selplg in Genome Data Viewer
    Location:
    12q16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (48457102..48470444)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (42796690..42809908)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (48577905..48579196)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene coronin 1C Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial-like Neighboring gene uncharacterized LOC108352466 Neighboring gene transmembrane protein 119

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver. Wyllie S, et al. World J Gastroenterol, 2008 Nov 28. PMID 19058306, Free PMC Article
    2. Molecular characterization of rat leukocyte P-selectin glycoprotein ligand-1 and effect of its blockade: protection from ischemia-reperfusion injury in liver transplantation. Tsuchihashi S, et al. J Immunol, 2006 Jan 1. PMID 16365457
    3. The sex-specific association of Met62Ile gene polymorphism in P-selectin glycoprotein ligand (PSGL-1) with carotid plaque presence: preliminary study. Zivković M, et al. Mol Biol Rep, 2012 Jun. PMID 22307784
    4. P-selectin glycoprotein ligand-1 is needed for sequential recruitment of T-helper 1 (Th1) and local generation of Th17 T cells in dextran sodium sulfate (DSS) colitis. Brown JB, et al. Inflamm Bowel Dis, 2012 Feb. PMID 22009715, Free PMC Article
    5. Evolutionary conservation of P-selectin glycoprotein ligand-1 primary structure and function. Baïsse B, et al. BMC Evol Biol, 2007 Sep 14. PMID 17868453, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to interleukin-6 ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte adhesive activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte tethering or rolling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukocyte tethering or rolling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of hepatocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in uropod ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    P-selectin glycoprotein ligand 1
    Names
    P-selectin glycoprotein ligand 1 propeptide
    leukocyte cell surface adhesion molecule
    selectin, platelet (p-selectin) ligand

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395153.1 → NP_001382082.1  P-selectin glycoprotein ligand 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6A4X3, A7WPA8, F6T9E7, Q8K5B0
      Related
      ENSRNOP00000082525.1, ENSRNOT00000096864.2
      Conserved Domains (1) summary
      PRK10811
      Location:95 → 282
      rne; ribonuclease E; Reviewed

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      48457102..48470444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089642.2 → XP_038945570.1  P-selectin glycoprotein ligand 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4X3, A7WPA8, F6T9E7, Q8K5B0
      Related
      ENSRNOP00000105316.1, ENSRNOT00000154708.1
      Conserved Domains (1) summary
      PRK10811
      Location:95 → 282
      rne; ribonuclease E; Reviewed

    2. XM_039089643.2 → XP_038945571.1  P-selectin glycoprotein ligand 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4X3, A7WPA8, F6T9E7, Q8K5B0
      Conserved Domains (1) summary
      PRK10811
      Location:95 → 282
      rne; ribonuclease E; Reviewed

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013230.1: Suppressed sequence

      Description
      NM_001013230.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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