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    Amz1 archaelysin family metallopeptidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304317, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Amz1provided by RGD
    Official Full Name
    archaelysin family metallopeptidase 1provided by RGD
    Primary source
    RGD:1311314
    See related
    EnsemblRapid:ENSRNOG00000077699 AllianceGenome:RGD:1311314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311314
    Summary
    Predicted to enable metal ion binding activity and metallopeptidase activity. Predicted to be involved in proteolysis. Orthologous to human AMZ1 (archaelysin family metallopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 46.3), Brain (RPKM 26.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Amz1 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19000448..19038625, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (13886518..13924275, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (15975211..16011238, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene caspase recruitment domain family, member 11 Neighboring gene G protein subunit alpha 12 Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene IQ motif containing E Neighboring gene tweety family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    archaemetzincin-1
    Names
    archeobacterial metalloproteinase-like 1
    archeobacterial metalloproteinase-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047092.3 → NP_001040557.1  archaemetzincin-1

      See identical proteins and their annotated locations for NP_001040557.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      B1H214, Q400C9
      Related
      ENSRNOP00000112722.1, ENSRNOT00000124296.1
      Conserved Domains (1) summary
      cd11375
      Location:95 → 305
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      19000448..19038625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271271.1 → XP_063127341.1  archaemetzincin-1 isoform X2

      Related
      ENSRNOP00000107909.1, ENSRNOT00000136049.1

    2. XM_006248930.5 → XP_006248992.1  archaemetzincin-1 isoform X1

      See identical proteins and their annotated locations for XP_006248992.1

      UniProtKB/Swiss-Prot
      B1H214, Q400C9
      Conserved Domains (1) summary
      cd11375
      Location:95 → 305
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

    3. XM_063271270.1 → XP_063127340.1  archaemetzincin-1 isoform X2

    4. XM_039089386.2 → XP_038945314.1  archaemetzincin-1 isoform X1

      UniProtKB/Swiss-Prot
      B1H214, Q400C9
      Conserved Domains (1) summary
      cd11375
      Location:95 → 305
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

    5. XM_006248932.5 → XP_006248994.1  archaemetzincin-1 isoform X1

      See identical proteins and their annotated locations for XP_006248994.1

      UniProtKB/Swiss-Prot
      B1H214, Q400C9
      Conserved Domains (1) summary
      cd11375
      Location:95 → 305
      Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q400C9.1 GenPept UniProtKB/Swiss-Prot:Q400C9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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