Spata18 spermatogenesis associated 18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spata18provided by RGD
Official Full Name: spermatogenesis associated 18provided by RGD
Primary source: RGD:735208
See related: EnsemblRapid:ENSRNOG00000002120 AllianceGenome:RGD:735208
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: spetex-1
Summary: Predicted to enable cardiolipin binding activity; identical protein binding activity; and molecular condensate scaffold activity. Predicted to be involved in several processes, including mitochondrial protein catabolic process; mitophagy by internal vacuole formation; and positive regulation of cardiolipin metabolic process. Located in sperm flagellum. Orthologous to human SPATA18 (spermatogenesis associated 18). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 877.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (34885995..34912704, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (34531931..34558671, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (37081529..37108245, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggested that Spetex-1, a new component of satellite fibrils, might be involved in the structural stability of the sperm flagellar middle piece and functions in co-operation with Tektin4.
Title: Characterization of Spetex-1, a new component of satellite fibrils associated with outer dense fibers in the middle piece of rodent sperm flagella.
potential role of spetex-1 in spermatogenesis, especially in cell differentiation
Title: Complementary DNA cloning of rat spetex-1, a spermatid-expressing gene-1, encoding a 63 kDa cytoplasmic protein of elongate spermatids.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cardiolipin binding	IEA Inferred from Electronic Annotation more info
enables cardiolipin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	IEA Inferred from Electronic Annotation more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitophagy by internal vacuole formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy by internal vacuole formation	IEA Inferred from Electronic Annotation more info
involved_in mitophagy by internal vacuole formation	ISO Inferred from Sequence Orthology more info
involved_in mitophagy by internal vacuole formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiolipin metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiolipin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membraneless organelle	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membraneless organelle	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mitochondria-eating protein

Names: spermatid-expressing gene 1 protein; spermatid-expressing gene-1; spermatogenesis-associated protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393794.1 → NP_001380723.1 mitochondria-eating protein isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A6JD28

Related

ENSRNOP00000101322.1, ENSRNOT00000135118.1

Conserved Domains (2) summary

COG1196
Location:95 → 238

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16026
Location:316 → 503

MIEAP; Mitochondria-eating protein
NM_199374.3 → NP_955406.2 mitochondria-eating protein isoform 1

See identical proteins and their annotated locations for NP_955406.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

D3ZEU0, Q6AYL6, Q764P0

UniProtKB/TrEMBL

A6JD28

Related

ENSRNOP00000095811.2, ENSRNOT00000099027.2

Conserved Domains (1) summary

pfam16026
Location:316 → 503

MIEAP; Mitochondria-eating protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

34885995..34912704 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091694.2 → XP_038947622.1 mitochondria-eating protein isoform X2

UniProtKB/TrEMBL

A6JD28

Conserved Domains (2) summary

COG1196
Location:123 → 266

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16026
Location:344 → 531

MIEAP; Mitochondria-eating protein
XM_039091693.2 → XP_038947621.1 mitochondria-eating protein isoform X1

UniProtKB/TrEMBL

A6JD28

Conserved Domains (2) summary

COG1196
Location:123 → 266

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16026
Location:344 → 531

MIEAP; Mitochondria-eating protein
XM_039091695.2 → XP_038947623.1 mitochondria-eating protein isoform X3

Conserved Domains (1) summary

COG1196
Location:123 → 268

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]