Nudt18 nudix hydrolase 18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nudt18provided by RGD
Official Full Name: nudix hydrolase 18provided by RGD
Primary source: RGD:1311802
See related: EnsemblRapid:ENSRNOG00000011831 AllianceGenome:RGD:1311802
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311802
Summary: Predicted to enable 8-hydroxy-dADP phosphatase activity; 8-oxo-GDP phosphatase activity; and 8-oxo-dGDP phosphatase activity. Predicted to be involved in GDP catabolic process; dADP catabolic process; and dGDP catabolic process. Orthologous to human NUDT18 (nudix hydrolase 18). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 211.5), Heart (RPKM 114.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (52060297..52062822)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (45650597..45653985)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (52265557..52268081)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 8-hydroxy-dADP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables 8-hydroxy-dADP phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 8-oxo-GDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 8-oxo-GDP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables 8-oxo-GDP phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 8-oxo-dGDP phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 8-oxo-dGDP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables 8-oxo-dGDP phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in GDP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in GDP catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in dADP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dADP catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in dGDP catabolic process	ISO Inferred from Sequence Orthology more info
involved_in dGDP catabolic process	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 8-oxo-dGDP phosphatase NUDT18

Names: 2-hydroxy-dADP phosphatase; 7,8-dihydro-8-oxoguanine phosphatase; mutT homolog 3; nucleoside diphosphate-linked moiety X motif 18; nudix (nucleoside diphosphate linked moiety X)-type motif 18; nudix motif 18

NP_001094202.1

EC 3.6.1.58

XP_038949443.1

EC 3.6.1.58

XP_038949444.1

EC 3.6.1.58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100732.1 → NP_001094202.1 8-oxo-dGDP phosphatase NUDT18

See identical proteins and their annotated locations for NP_001094202.1

Status: PROVISIONAL

Source sequence(s)

BC158874

UniProtKB/Swiss-Prot

Q4KM80, Q641Y7

UniProtKB/TrEMBL

B0BNL9

Related

ENSRNOP00000015969.4, ENSRNOT00000015969.8

Conserved Domains (1) summary

cd04671
Location:44 → 166

Nudix_Hydrolase_13; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

52060297..52062822

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093516.2 → XP_038949444.1 8-oxo-dGDP phosphatase NUDT18 isoform X2

Conserved Domains (1) summary

cl00447
Location:1 → 108

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
XM_039093515.2 → XP_038949443.1 8-oxo-dGDP phosphatase NUDT18 isoform X1

Conserved Domains (1) summary

cl00447
Location:14 → 126

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...