Ly86 lymphocyte antigen 86 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ly86provided by RGD
Official Full Name: lymphocyte antigen 86provided by RGD
Primary source: RGD:1309936
See related: EnsemblRapid:ENSRNOG00000000137 AllianceGenome:RGD:1309936
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in innate immune response and positive regulation of lipopolysaccharide-mediated signaling pathway. Orthologous to human LY86 (lymphocyte antigen 86). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 194.9), Thymus (RPKM 52.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (27621313..27705336, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (27415807..27499695, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (28104535..28191447, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lymphocyte antigen 86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106128.1 → NP_001099598.1 lymphocyte antigen 86

See identical proteins and their annotated locations for NP_001099598.1

Status: PROVISIONAL

Source sequence(s)

CH473977

UniProtKB/TrEMBL

A6J7C7, D3ZAS0

Related

ENSRNOP00000000149.5, ENSRNOT00000000149.8

Conserved Domains (1) summary

cl00274
Location:55 → 184

ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

27621313..27705336 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006253800.5 → XP_006253862.1 lymphocyte antigen 86 isoform X1

See identical proteins and their annotated locations for XP_006253862.1

UniProtKB/TrEMBL

A6J7C7, D3ZAS0

Conserved Domains (1) summary

cl00274
Location:55 → 184

ML; The ML (MD-2-related lipid-recognition) domain is present in MD-1, MD-2, GM2 activator protein, Niemann-Pick type C2 (Npc2) protein, phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP), mite allergen Der p 2 and several proteins of ...