Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp21a1provided by RGD
Official Full Name: cytochrome P450, family 21, subfamily a, polypeptide 1provided by RGD
Primary source: RGD:2461
See related: EnsemblRapid:ENSRNOG00000000428 AllianceGenome:RGD:2461
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 21-OH; Cyp21
Summary: Enables steroid 21-monooxygenase activity. Involved in C21-steroid hormone metabolic process; cellular response to peptide hormone stimulus; and mineralocorticoid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to several human genes including CYP21A2 (cytochrome P450 family 21 subfamily A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 17893.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4028323..4031549)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4020217..4026923)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (4486213..4489358, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of steroid 21-hydroxylase has been detected in cultured rat cerebellar astrocytes.
Title: Steroid 21-hydroxylase expression in cultured rat astrocytes.

Submit: New GeneRIF Correction

General gene information

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Markers

RH94616 (e-PCR)
- UniSTS:119864

RH134814 (e-PCR)
- UniSTS:218092

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 17-hydroxyprogesterone 21-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables 17-hydroxyprogesterone 21-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables progesterone 21-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables progesterone 21-hydroxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables steroid 21-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables steroid 21-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in C21-steroid hormone biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to peptide hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in glucocorticoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mineralocorticoid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in progesterone metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in steroid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: steroid 21-hydroxylase

Names: 21-OHase; Cytochrome P450 subfamily XXI (steroid 21-hydroxylase); P-450c21; P450-C21; cytochrome P-450c21; cytochrome P450 21 steroid 21 hydroxylase; cytochrome P450 XXI; cytochrome P450, subfamily 21A, polypeptide 1; cytochrome P450, subfamily XXI (steroid 21-hydroxylase); cytochrome P450-C21

NP_476442.2

EC 1.14.14.16

XP_006255969.1

EC 1.14.14.16

XP_063135021.1

EC 1.14.14.16

XP_063135022.1

EC 1.14.14.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057101.2 → NP_476442.2 steroid 21-hydroxylase

Status: VALIDATED

Source sequence(s)

BX883044

UniProtKB/Swiss-Prot

Q64562

UniProtKB/TrEMBL

F1LRG0

Related

ENSRNOP00000037516.3, ENSRNOT00000031548.5

Conserved Domains (1) summary

pfam00067
Location:31 → 474

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

4028323..4031549

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063278952.1 → XP_063135022.1 steroid 21-hydroxylase isoform X3
XM_063278951.1 → XP_063135021.1 steroid 21-hydroxylase isoform X2

UniProtKB/Swiss-Prot

Q64562
XM_006255907.4 → XP_006255969.1 steroid 21-hydroxylase isoform X1

UniProtKB/Swiss-Prot

Q64562

Conserved Domains (1) summary

pfam00067
Location:31 → 473

p450; Cytochrome P450