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    Depdc7 DEP domain containing 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295971, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Depdc7provided by RGD
    Official Full Name
    DEP domain containing 7provided by RGD
    Primary source
    RGD:1309720
    See related
    EnsemblRapid:ENSRNOG00000012262 AllianceGenome:RGD:1309720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309720
    Summary
    Predicted to be involved in intracellular signal transduction. Orthologous to human DEPDC7 (DEP domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 650.3), Kidney (RPKM 184.4) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Depdc7 in Genome Data Viewer
    Location:
    3q32
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (111554701..111575979, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (91099111..91121152, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (94665714..94687013, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene cleavage stimulation factor subunit 3 Neighboring gene t-complex 11 like 1 Neighboring gene uncharacterized LOC134486132 Neighboring gene glutamine and serine rich 1 Neighboring gene proline rich and Gla domain 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114389

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DEP domain-containing protein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029916.1 → NP_001025087.1  DEP domain-containing protein 7 isoform 1

      See identical proteins and their annotated locations for NP_001025087.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097357
      UniProtKB/Swiss-Prot
      Q4QR86
      UniProtKB/TrEMBL
      A6HNU9
      Related
      ENSRNOP00000016677.5, ENSRNOT00000016677.7
      Conserved Domains (2) summary
      cd04405
      Location:192 → 425
      RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...
      cd04446
      Location:39 → 133
      DEP_DEPDC4; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.

    2. NM_001429957.1 → NP_001416886.1  DEP domain-containing protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZY15

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      111554701..111575979 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104531.2 → XP_038960459.1  DEP domain-containing protein 7 isoform X1

      Related
      ENSRNOP00000082907.1, ENSRNOT00000111299.2
      Conserved Domains (2) summary
      cd04405
      Location:179 → 412
      RhoGAP_BRCC3-like; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal ...
      cd04446
      Location:26 → 120
      DEP_DEPDC4; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QR86.1 GenPept UniProtKB/Swiss-Prot:Q4QR86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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