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    Eef1b2 eukaryotic translation elongation factor 1 beta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363241, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eef1b2provided by RGD
    Official Full Name
    eukaryotic translation elongation factor 1 beta 2provided by RGD
    Primary source
    RGD:1311415
    See related
    EnsemblRapid:ENSRNOG00000024186 AllianceGenome:RGD:1311415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Involved in response to ethanol. Predicted to be located in endoplasmic reticulum. Predicted to be part of eukaryotic translation elongation factor 1 complex. Predicted to be active in cytosol. Orthologous to human EEF1B2 (eukaryotic translation elongation factor 1 beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 1112.7), Thymus (RPKM 1035.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eef1b2 in Genome Data Viewer
    Location:
    9q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (72074091..72076591)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (64580163..64582737)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (69953440..69956158)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene NOP16 nucleolar protein, pseudogene 2 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S1 Neighboring gene small nucleolar RNA, C/D box 51 Neighboring gene small nucleolar RNA, H/ACA box 41 Neighboring gene chemerin chemokine-like receptor 2 Neighboring gene zinc finger, DBF-type containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Prenatal alcohol exposure alters phosphorylation and glycosylation of proteins in rat offspring liver. Fofana B, et al. Proteomics, 2010 Feb. PMID 19941308
    2. The elongation, termination, and recycling phases of translation in eukaryotes. Dever TE, et al. Cold Spring Harb Perspect Biol, 2012 Jul 1. PMID 22751155, Free PMC Article
    3. Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. Sanders J, et al. J Cell Sci, 1996 May. PMID 8743958
    4. Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. Bohnsack MT, et al. EMBO J, 2002 Nov 15. PMID 12426392, Free PMC Article
    5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic translation elongation factor 1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    elongation factor 1-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108799.3 → NP_001102269.1  elongation factor 1-beta

      See identical proteins and their annotated locations for NP_001102269.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AEG7, A6IPG1, B5DEN5, F6SZC1
      Related
      ENSRNOP00000036882.4, ENSRNOT00000034740.6
      Conserved Domains (3) summary
      cd10308
      Location:3 → 62
      GST_C_eEF1b_like; Glutathione S-transferase C-terminal-like, alpha helical domain of eukaryotic translation Elongation Factor 1 beta
      pfam00736
      Location:142 → 225
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:103 → 130
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      72074091..72076591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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