U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    sec-31 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178060, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    sec-31
    Official Full Name
    WD_REPEATS_REGION domain-containing protein
    Primary source
    WormBase:WBGene00011338
    Locus tag
    CELE_T01G1.3
    See related
    AllianceGenome:WB:WBGene00011338
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable structural molecule activity. Predicted to be involved in COPII-coated vesicle cargo loading and endoplasmic reticulum organization. Predicted to be located in endoplasmic reticulum. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in Halperin-Birk syndrome. Orthologous to several human genes including SEC31A (SEC31 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See sec-31 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    16
    Sequence:
    Chromosome: IV; NC_003282.8 (11365621..11371792, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene tRNA Neighboring gene Chitin-binding domain protein cbd-1 Neighboring gene F-box domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Sar1 GTPase Activity Is Regulated by Membrane Curvature. Hanna MG 4th, et al. J Biol Chem, 2016 Jan 15. PMID 26546679, Free PMC Article
    2. ERGIC2 and ERGIC3 regulate the ER-to-Golgi transport of gap junction proteins in metazoans. Guan L, et al. Traffic, 2022 Mar. PMID 34994051
    3. TFG-1 function in protein secretion and oncogenesis. Witte K, et al. Nat Cell Biol, 2011 May. PMID 21478858, Free PMC Article
    4. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. Zhang Z, et al. PLoS Genet, 2021 Feb. PMID 33524011, Free PMC Article
    5. ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1. Wang W, et al. Traffic, 2008 May. PMID 18298590, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    WD_REPEATS_REGION domain-containing protein
    NP_502144.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11365621..11371792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069743.7 → NP_502144.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502144.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFY6
      Conserved Domains (3) summary
      sd00039
      Location:71 → 119
      7WD40; WD40 repeat [structural motif]
      pfam03154
      Location:773 → 895
      Atrophin-1; Atrophin-1 family
      cl29593
      Location:72 → 311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous