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    • Showing Current items.

    nep-1 Neprilysin-1 [ Caenorhabditis elegans ]

    Gene ID: 174787, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nep-1
    Official Full Name
    Neprilysin-1
    Primary source
    WormBase:WBGene00013926
    Locus tag
    CELE_ZK20.6
    See related
    AllianceGenome:WB:WBGene00013926
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in RIH and pharynx. Human ortholog(s) of this gene implicated in Alzheimer's disease; congestive heart failure; coronary artery disease; essential hypertension; and hypertension. Orthologous to several human genes including ECE1 (endothelin converting enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nep-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (11654208..11657179, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene UV excision repair protein RAD23 Neighboring gene 26S proteasome non-ATPase regulatory subunit 8 Neighboring gene ncRNA Neighboring gene Transcription-associated protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans neprilysin NEP-1: an effector of locomotion and pharyngeal pumping. Spanier B, et al. J Mol Biol, 2005 Sep 16. PMID 16081104
    2. Systematic analysis of genes required for synapse structure and function. Sieburth D, et al. Nature, 2005 Jul 28. PMID 16049479
    3. A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins. Kamal M, et al. Elife, 2022 Oct 19. PMID 36259463, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZK20.6 enzyme plays an important role in the regulation of nematode locomotion
      Title: Caenorhabditis elegans neprilysin NEP-1: an effector of locomotion and pharyngeal pumping.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Neprilysin-1
    NP_496490.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11654208..11657179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064089.7 → NP_496490.2  Neprilysin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496490.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q18673, Q23453
      Conserved Domains (1) summary
      cd08662
      Location:85 → 751
      M13; Peptidase family M13 includes neprilysin and endothelin-converting enzyme I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q18673.3

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