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    txdc-17 Thioredoxin domain-containing protein 17 [ Caenorhabditis elegans ]

    Gene ID: 175400, updated on 9-Dec-2024

    Summary

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    Official Symbol
    txdc-17
    Official Full Name
    Thioredoxin domain-containing protein 17
    Primary source
    WormBase:WBGene00022188
    Locus tag
    CELE_Y71H2AR.1
    See related
    AllianceGenome:WB:WBGene00022188
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-disulfide reductase (NAD(P)H) activity. Predicted to be active in cytosol. Orthologous to human TXNDC17 (thioredoxin domain containing 17). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See txdc-17 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (2834663..2836261)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Neighboring gene N(6)-L-threonylcarbamoyladenine synthase Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ubiquitinyl hydrolase 1 Neighboring gene Peptidase C1A papain C-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRP14 is the rate-limiting enzyme for intracellular cystine reduction and regulates proteome cysteinylation. Martí-Andrés P, et al. EMBO J, 2024 Jul. PMID 38811853, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein-disulfide reductase (NAD(P)H) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase (NAD(P)H) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Thioredoxin domain-containing protein 17
    NP_497626.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2834663..2836261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065225.6 → NP_497626.1  Thioredoxin domain-containing protein 17 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497626.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL27
      Conserved Domains (1) summary
      cl00388
      Location:8 → 130
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version

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