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    glp-4 Valine--tRNA ligase [ Caenorhabditis elegans ]

    Gene ID: 173224, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glp-4
    Official Full Name
    Valine--tRNA ligase
    Primary source
    WormBase:WBGene00006936
    Locus tag
    CELE_Y87G2A.5
    See related
    AllianceGenome:WB:WBGene00006936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable valine-tRNA ligase activity. Involved in determination of adult lifespan. Predicted to be active in cytosol. Orthologous to human VARS1 (valyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glp-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (13548074..13559361, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Cysteine protease atg-4.1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene small monomeric GTPase Neighboring gene Carbohydrate sulfotransferase Neighboring gene Ground-like domain-containing protein Neighboring gene peptidylprolyl isomerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yersinia enterocolitica infection and tcaA-dependent killing of Caenorhabditis elegans. Spanier B, et al. Appl Environ Microbiol, 2010 Sep. PMID 20639372, Free PMC Article
    2. Repurposing bioactive compounds for treating multidrug-resistant pathogens. Hummell NA, et al. J Med Microbiol, 2020 Jun. PMID 32163353, Free PMC Article
    3. Early experiences mediate distinct adult gene expression and reproductive programs in Caenorhabditis elegans. Ow MC, et al. PLoS Genet, 2018 Feb. PMID 29447162, Free PMC Article
    4. A robust and miniaturized screening platform to study natural products affecting metabolism and survival in Caenorhabditis elegans. Zwirchmayr J, et al. Sci Rep, 2020 Jul 23. PMID 32704017, Free PMC Article
    5. Caenorhabditis elegans glp-4 Encodes a Valyl Aminoacyl tRNA Synthetase. Rastogi S, et al. G3 (Bethesda), 2015 Oct 13. PMID 26464357, Free PMC Article

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA editing activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables valine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables valine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aminoacyl-tRNA metabolism involved in translational fidelity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in valyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in valyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Valine--tRNA ligase
    NP_493377.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13548074..13559361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060976.7 → NP_493377.1  Valine--tRNA ligase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493377.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U1Q4
      Conserved Domains (5) summary
      cd07962
      Location:718 → 856
      Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
      cd00817
      Location:118 → 718
      ValRS_core; catalytic core domain of valyl-tRNA synthetases
      PTZ00419
      Location:51 → 1050
      PTZ00419; valyl-tRNA synthetase-like protein; Provisional
      pfam10458
      Location:982 → 1047
      Val_tRNA-synt_C; Valyl tRNA synthetase tRNA binding arm
      pfam13603
      Location:301 → 426
      tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U1Q4.1

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