arx-7 Actin-related protein 2/3 complex subunit 5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: arx-7
Official Full Name: Actin-related protein 2/3 complex subunit 5
Primary source: WormBase:WBGene00000205
Locus tag: CELE_M01B12.3
See related: AllianceGenome:WB:WBGene00000205
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin filament binding activity. Involved in Arp2/3 complex-mediated actin nucleation; epithelial cell migration; and morphogenesis of embryonic epithelium. Located in cytoplasm. Is expressed in anchor cell; hypodermis; and linker cell. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human ARPC5 (actin related protein 2/3 complex subunit 5) and ARPC5L (actin related protein 2/3 complex subunit 5 like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See arx-7 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (3069325..3070150, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arp2/3 affects the efficiency of rapid endocytic recycling of polarity cues that ultimately contributes to their stable maintenance.
Title: Arp2/3 mediates early endosome dynamics necessary for the maintenance of PAR asymmetry in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M01B12.3 (e-PCR)
- UniSTS:316074

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	IEA Inferred from Electronic Annotation more info
involved_in Arp2/3 complex-mediated actin nucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of embryonic epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Actin-related protein 2/3 complex subunit 5

NP_001379803.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3069325..3070150 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001393172.1 → NP_001379803.1 Actin-related protein 2/3 complex subunit 5 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O61861

Conserved Domains (1) summary

pfam04699
Location:9 → 150

P16-Arc; ARP2/3 complex 16 kDa subunit (p16-Arc)