gcy-18 Receptor-type guanylate cyclase gcy-18 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gcy-18
Official Full Name: Receptor-type guanylate cyclase gcy-18
Primary source: WormBase:WBGene00001543
Locus tag: CELE_ZK896.8
See related: AllianceGenome:WB:WBGene00001543
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable guanylate cyclase activity and peptide receptor activity. Involved in detection of temperature stimulus; thermosensory behavior; and thermotaxis. Located in microvillus membrane and neuron projection terminus. Is expressed in intestine and nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gcy-18 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 15

Sequence:: Chromosome: IV; NC_003282.8 (12860097..12865956)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

three guanylyl cyclases (gcy-8, gcy-18, and gcy-23) function redundantly in the AFD neurons to mediate thermosensation by C. elegans
Title: Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK896.8 (e-PCR)
- UniSTS:308326

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IEA Inferred from Electronic Annotation more info
enables guanylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in detection of temperature stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detection of temperature stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor guanylyl cyclase signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in thermosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thermotaxis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Receptor-type guanylate cyclase gcy-18

NP_502449.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

12860097..12865956

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_070048.7 → NP_502449.2 Receptor-type guanylate cyclase gcy-18 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502449.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EFQ0

Conserved Domains (6) summary

smart00044
Location:882 → 1073

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:909 → 1095

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam01094
Location:87 → 395

ANF_receptor; Receptor family ligand binding region

pfam07701
Location:857 → 903

HNOBA; Heme NO binding associated

cl10011
Location:87 → 448

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21453
Location:549 → 846

PKc_like; Protein Kinases, catalytic domain