mca-1 Plasma membrane calcium-transporting ATPase mca-1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: mca-1
Official Full Name: Plasma membrane calcium-transporting ATPase mca-1
Primary source: WormBase:WBGene00003151
Locus tag: CELE_W09C2.3
See related: AllianceGenome:WB:WBGene00003151
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables P-type calcium transporter activity and calmodulin binding activity. Involved in calcium ion transport and intracellular calcium ion homeostasis. Located in membrane. Is expressed in excretory canal. [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See mca-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 12

Sequence:: Chromosome: IV; NC_003282.8 (9625909..9634948, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

W09C2.3 (e-PCR)
- UniSTS:308164

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Plasma membrane calcium-transporting ATPase mca-1

NP_001023426.1

Partially confirmed by transcript evidence

NP_001023427.1

Confirmed by transcript evidence

NP_001255409.1

Confirmed by transcript evidence

NP_501709.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9625909..9634948 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028256.7 → NP_001023427.1 Plasma membrane calcium-transporting ATPase mca-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EC04

Conserved Domains (5) summary

TIGR01517
Location:43 → 1084

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam00122
Location:222 → 465

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:902 → 1080

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:63 → 130

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam13246
Location:529 → 621

Cation_ATPase; Cation transport ATPase (P-type)
NM_001028255.5 → NP_001023426.1 Plasma membrane calcium-transporting ATPase mca-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EC39

Conserved Domains (5) summary

TIGR01517
Location:5 → 1063

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam00122
Location:201 → 444

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:881 → 1059

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:42 → 109

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam13246
Location:508 → 600

Cation_ATPase; Cation transport ATPase (P-type)
NM_069308.6 → NP_501709.2 Plasma membrane calcium-transporting ATPase mca-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

F5GU98, G5EC04, G5EC39, G5EFR6

Conserved Domains (5) summary

TIGR01517
Location:46 → 1087

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam00122
Location:225 → 468

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:905 → 1083

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:66 → 133

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam13246
Location:532 → 624

Cation_ATPase; Cation transport ATPase (P-type)
NM_001268480.3 → NP_001255409.1 Plasma membrane calcium-transporting ATPase mca-1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

F5GU98

Conserved Domains (4) summary

TIGR01494
Location:40 → 760

ATPase_P-type; ATPase, P-type (transporting), HAD superfamily, subfamily IC

pfam00122
Location:58 → 301

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:738 → 916

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam13246
Location:365 → 457

Cation_ATPase; Cation transport ATPase (P-type)