U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    coh-1 Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein;Rad21_Rec8 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181003, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    coh-1
    Official Full Name
    Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein;Rad21_Rec8 domain-containing protein
    Primary source
    WormBase:WBGene00000591
    Locus tag
    CELE_K08A8.3
    See related
    AllianceGenome:WB:WBGene00000591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in replication-born double-strand break repair via sister chromatid exchange and sister chromatid cohesion. Predicted to be located in nucleus. Predicted to be part of cohesin complex. Is expressed in several structures, including anterior gonad arm and germ line. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; endometrial cancer; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human RAD21 (RAD21 cohesin complex component) and RAD21L1 (RAD21 cohesin complex component like 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See coh-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Sequence:
    Chromosome: X; NC_003284.9 (7465193..7475018, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Dual specificity mitogen-activated protein kinase kinase mek-1

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. MicroRNAs as potential agents to alter resistance to cytotoxic anticancer therapy. Weidhaas JB, et al. Cancer Res, 2007 Dec 1. PMID 18056433, Free PMC Article
    2. Distinct developmental function of two Caenorhabditis elegans homologs of the cohesin subunit Scc1/Rad21. Mito Y, et al. Mol Biol Cell, 2003 Jun. PMID 12808038, Free PMC Article
    3. Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. McCracken S, et al. J Biol Chem, 2005 Dec 23. PMID 16159877
    4. Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners. Schleiffer A, et al. Mol Cell, 2003 Mar. PMID 12667442
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in replication-born double-strand break repair via sister chromatid exchange IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cohesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein;Rad21_Rec8 domain-containing protein
    NP_001309700.1
    • Confirmed by transcript evidence
    NP_001309701.1
    • Confirmed by transcript evidence
    NP_001368598.1
    • Confirmed by transcript evidence
    NP_509262.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7465193..7475018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076861.8 → NP_509262.2  Rad21_Rec8 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBD0
      Conserved Domains (2) summary
      pfam04824
      Location:539 → 591
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
      pfam04825
      Location:1 → 97
      Rad21_Rec8_N; N-terminus of Rad21 / Rec8 like protein

    2. NM_001322622.4 → NP_001309700.1  Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBB4
      Conserved Domains (1) summary
      pfam04824
      Location:106 → 158
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein

    3. NM_001322623.4 → NP_001309701.1  Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MBV3
      Conserved Domains (1) summary
      pfam04824
      Location:79 → 131
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein

    4. NM_001381024.1 → NP_001368598.1  Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A131MCR9
      Conserved Domains (1) summary
      pfam04824
      Location:1 → 45
      Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.