unc-89 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-89
Official Full Name: Muscle M-line assembly protein unc-89
Primary source: WormBase:WBGene00006820
Locus tag: CELE_C09D1.1
See related: AllianceGenome:WB:WBGene00006820
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables MATH domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Involved in several processes, including myofibril assembly; nematode pharyngeal gland morphogenesis; and regulation of striated muscle contraction. Located in M band. Is expressed in several structures, including alimentary muscle; body wall musculature; pharynx; tail; and vulval muscle. Human ortholog(s) of this gene implicated in centronuclear myopathy 5. Orthologous to human SPEG (striated muscle enriched protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See unc-89 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 51

Sequence:: Chromosome: I; NC_003279.8 (4035702..4090885)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function.
Title: Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function.
A Region of UNC-89 (Obscurin) Lying between Two Protein Kinase Domains Is a Highly Elastic Spring Required for Proper Sarcomere Organization.
Title: A Region of UNC-89 (Obscurin) Lying between Two Protein Kinase Domains Is a Highly Elastic Spring Required for Proper Sarcomere Organization.
study demonstrates that the level of MEI-1 protein is reduced in an unc-89 mutant, indicating that the normal role of UNC-89 is to inhibit the CUL-3/MEL-26 complex toward MEI-1 in striated muscle
Title: UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.
data implicates UNC-89 in maintaining muscle cell architecture and that this precise organization is essential for optimal calcium mobilization and efficient and effective muscle contraction.
Title: Large isoforms of UNC-89 (obscurin) are required for muscle cell architecture and optimal calcium release in Caenorhabditis elegans.
SCPL-1 interacts with LIM-9 (FHL), a protein that we first discovered as an interactor of UNC-97 (PINCH) and UNC-96, components of an M-line costamere in nematode muscle.
Title: A LIM-9 (FHL)/SCPL-1 (SCP) complex interacts with the C-terminal protein kinase regions of UNC-89 (obscurin) in Caenorhabditis elegans muscle.
Yeast two-hybrid screening using a portion of UNC-89 including PK2, yielded SCPL-1 (small CTD phosphatase-like-1), which contains a C terminal domain (CTD) phosphatase type domain.
Title: A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans.
Results support a model in which the DH-PH region of UNC-89 activates RHO-1 GTPase for organization of myosin filaments in C. elegans muscle cells.
Title: The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle.
Results show that the coding sequence for unc-89 is larger than originally thought, and that the gene encodes at least four major isoforms.
Title: Three new isoforms of Caenorhabditis elegans UNC-89 containing MLCK-like protein kinase domains.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C09D1.1 (e-PCR)
- UniSTS:308524

C09D1.2 (e-PCR)
- UniSTS:315463

C24G7.5 (e-PCR)
- UniSTS:309139

STS1-146 (e-PCR)
- UniSTS:241632

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MATH domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
NOT enables inositol 1,4,5 trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in muscle structure development	IEA Inferred from Electronic Annotation more info
involved_in myosin filament assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode pharyngeal gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein localization to endoplasmic reticulum	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of striated muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
NOT involved_in regulation of protein localization to endoplasmic reticulum	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of skeletal muscle contraction by calcium ion signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in skeletal muscle myosin thick filament assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in striated muscle myosin thick filament assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in A band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in organelle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Muscle M-line assembly protein unc-89

NP_001020984.1

Confirmed by transcript evidence

NP_001020985.1

Confirmed by transcript evidence

NP_001020988.1

Confirmed by transcript evidence

NP_001020989.1

Confirmed by transcript evidence

NP_001293453.1

Confirmed by transcript evidence

NP_001293454.1

Confirmed by transcript evidence

NP_001343617.1

Partially confirmed by transcript evidence

NP_001343711.1

Partially confirmed by transcript evidence

NP_001343712.1

Partially confirmed by transcript evidence

NP_001343713.1

Partially confirmed by transcript evidence

NP_001343714.1

Confirmed by transcript evidence

NP_001343715.1

Confirmed by transcript evidence

NP_001343716.1

Confirmed by transcript evidence

NP_001343717.1

Confirmed by transcript evidence

NP_001343718.1

Confirmed by transcript evidence

NP_001343719.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4035702..4090885

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025813.2 → NP_001020984.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020984.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01761

Conserved Domains (13) summary

cd00096
Location:5614 → 5681

Ig; Immunoglobulin domain

cd04972
Location:2075 → 2164

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00408
Location:5501 → 5567

IGc2; Immunoglobulin C-2 Type

smart00060
Location:6275 → 6358

FN3; Fibronectin type 3 domain

smart00410
Location:6413 → 6501

IG_like; Immunoglobulin like

cd00160
Location:153 → 328

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam07679
Location:648 → 737

I-set; Immunoglobulin I-set domain

cd13325
Location:341 → 455

PH_unc89; unc89 pleckstrin homology (PH) domain

TIGR04420
Location:1625 → 1800

Sec_Non_Glob; Sec region non-globular protein

pfam05177
Location:1576 → 1678

RCSD; RCSD region

pfam16496
Location:1425 → 1499

SWIRM-assoc_2; SWIRM-associated domain at the N-terminal

cl11960
Location:5094 → 5161

Ig; Immunoglobulin domain

cl17036
Location:65 → 124

SH3; Src Homology 3 domain superfamily
NM_001025814.4 → NP_001020985.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020985.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01761, Q17362, Q5W614, Q5W615, Q5W616, Q5W617, Q646H5, Q64EQ8, Q7Z119, Q7Z120

Conserved Domains (15) summary

cd00096
Location:5614 → 5681

Ig; Immunoglobulin domain

cd04972
Location:2075 → 2164

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00408
Location:5501 → 5567

IGc2; Immunoglobulin C-2 Type

smart00060
Location:6275 → 6358

FN3; Fibronectin type 3 domain

smart00220
Location:6640 → 6878

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00410
Location:6413 → 6501

IG_like; Immunoglobulin like

cd00063
Location:7621 → 7716

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:153 → 328

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam07679
Location:648 → 737

I-set; Immunoglobulin I-set domain

cd13325
Location:341 → 455

PH_unc89; unc89 pleckstrin homology (PH) domain

cd14109
Location:6620 → 6878

PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cd14112
Location:7781 → 8035

STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

pfam05177
Location:1576 → 1678

RCSD; RCSD region

cl11960
Location:5094 → 5161

Ig; Immunoglobulin domain

cl17036
Location:65 → 124

SH3; Src Homology 3 domain superfamily
NM_001356807.3 → NP_001343717.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3B7

Conserved Domains (11) summary

cd04972
Location:2075 → 2164

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00060
Location:5555 → 5638

FN3; Fibronectin type 3 domain

cd00063
Location:6901 → 6996

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:153 → 328

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam07679
Location:648 → 737

I-set; Immunoglobulin I-set domain

cd13325
Location:341 → 455

PH_unc89; unc89 pleckstrin homology (PH) domain

cd14112
Location:7061 → 7315

STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cl17036
Location:65 → 124

SH3; Src Homology 3 domain superfamily

cl21453
Location:5900 → 6158

PKc_like; Protein Kinases, catalytic domain

cl26511
Location:1345 → 1992

Neuromodulin_N; Gap junction protein N-terminal region

cl28434
Location:4557 → 4647

I-set; Immunoglobulin I-set domain
NM_001356808.3 → NP_001343716.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2W9

Conserved Domains (11) summary

cd04972
Location:2075 → 2164

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00060
Location:5702 → 5785

FN3; Fibronectin type 3 domain

cd00063
Location:7048 → 7143

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:153 → 328

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam07679
Location:648 → 737

I-set; Immunoglobulin I-set domain

cd13325
Location:341 → 455

PH_unc89; unc89 pleckstrin homology (PH) domain

cd14112
Location:7208 → 7462

STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cl17036
Location:65 → 124

SH3; Src Homology 3 domain superfamily

cl21453
Location:6047 → 6305

PKc_like; Protein Kinases, catalytic domain

cl26511
Location:1304 → 1992

Neuromodulin_N; Gap junction protein N-terminal region

cl28434
Location:946 → 1034

I-set; Immunoglobulin I-set domain
NM_001356809.3 → NP_001343714.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2S8

Conserved Domains (11) summary

cd04972
Location:2053 → 2142

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00060
Location:6253 → 6336

FN3; Fibronectin type 3 domain

cd00063
Location:7599 → 7694

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:153 → 328

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam07679
Location:648 → 737

I-set; Immunoglobulin I-set domain

cd13325
Location:341 → 455

PH_unc89; unc89 pleckstrin homology (PH) domain

cd14109
Location:6598 → 6856

PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cd14112
Location:7759 → 8013

STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cl17036
Location:65 → 124

SH3; Src Homology 3 domain superfamily

cl26511
Location:1323 → 1970

Neuromodulin_N; Gap junction protein N-terminal region

cl28434
Location:946 → 1034

I-set; Immunoglobulin I-set domain
NM_001025818.3 → NP_001020989.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020989.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01761

Conserved Domains (14) summary

cd00096
Location:4974 → 5041

Ig; Immunoglobulin domain

cd04972
Location:1435 → 1524

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00408
Location:4861 → 4927

IGc2; Immunoglobulin C-2 Type

cd12025
Location:65 → 124

SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins

smart00060
Location:5635 → 5718

FN3; Fibronectin type 3 domain

smart00220
Location:6000 → 6238

S_TKc; Serine/Threonine protein kinases, catalytic domain

smart00409
Location:5773 → 5861

IG; Immunoglobulin

cd00063
Location:6981 → 7076

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00160
Location:153 → 328

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam07679
Location:648 → 737

I-set; Immunoglobulin I-set domain

cd13325
Location:341 → 455

PH_unc89; unc89 pleckstrin homology (PH) domain

cd14112
Location:7141 → 7395

STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cl11960
Location:4454 → 4521

Ig; Immunoglobulin domain

cl21453
Location:5980 → 6238

PKc_like; Protein Kinases, catalytic domain
NM_001356810.3 → NP_001343718.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C365

Conserved Domains (8) summary

cd04972
Location:2075 → 2164

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00060
Location:5555 → 5638

FN3; Fibronectin type 3 domain

cd00160
Location:153 → 328

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam07679
Location:648 → 737

I-set; Immunoglobulin I-set domain

cd13325
Location:341 → 455

PH_unc89; unc89 pleckstrin homology (PH) domain

cl17036
Location:65 → 124

SH3; Src Homology 3 domain superfamily

cl26511
Location:1304 → 1992

Neuromodulin_N; Gap junction protein N-terminal region

cl28434
Location:2269 → 2360

I-set; Immunoglobulin I-set domain
NM_001356811.3 → NP_001343715.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C330

Conserved Domains (8) summary

cd04972
Location:2053 → 2142

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00060
Location:6253 → 6336

FN3; Fibronectin type 3 domain

cd00160
Location:153 → 328

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam07679
Location:648 → 737

I-set; Immunoglobulin I-set domain

cd13325
Location:341 → 455

PH_unc89; unc89 pleckstrin homology (PH) domain

cl17036
Location:65 → 124

SH3; Src Homology 3 domain superfamily

cl26511
Location:1282 → 1970

Neuromodulin_N; Gap junction protein N-terminal region

cl28434
Location:2247 → 2338

I-set; Immunoglobulin I-set domain
NM_001025817.4 → NP_001020988.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001020988.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01761

Conserved Domains (10) summary

cd00096
Location:4974 → 5041

Ig; Immunoglobulin domain

cd04972
Location:1435 → 1524

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00408
Location:4861 → 4927

IGc2; Immunoglobulin C-2 Type

cd12025
Location:65 → 124

SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins

smart00060
Location:5635 → 5718

FN3; Fibronectin type 3 domain

smart00409
Location:5773 → 5861

IG; Immunoglobulin

cd00160
Location:153 → 328

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

pfam07679
Location:648 → 737

I-set; Immunoglobulin I-set domain

cd13325
Location:341 → 455

PH_unc89; unc89 pleckstrin homology (PH) domain

cl11960
Location:4454 → 4521

Ig; Immunoglobulin domain
NM_001356812.3 → NP_001343617.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (8) summary

cd04972
Location:1602 → 1691

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00060
Location:5802 → 5885

FN3; Fibronectin type 3 domain

cd00063
Location:7148 → 7243

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:175 → 264

I-set; Immunoglobulin I-set domain

cd14109
Location:6147 → 6405

PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cd14112
Location:7308 → 7562

STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cl26511
Location:872 → 1519

Neuromodulin_N; Gap junction protein N-terminal region

cl28434
Location:473 → 561

I-set; Immunoglobulin I-set domain
NM_001356813.3 → NP_001343719.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2G8

Conserved Domains (8) summary

cd04972
Location:1602 → 1691

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00060
Location:5082 → 5165

FN3; Fibronectin type 3 domain

cd00063
Location:6428 → 6523

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:175 → 264

I-set; Immunoglobulin I-set domain

cd14109
Location:5427 → 5685

PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cd14112
Location:6588 → 6842

STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cl26511
Location:860 → 1519

Neuromodulin_N; Gap junction protein N-terminal region

cl28434
Location:473 → 561

I-set; Immunoglobulin I-set domain
NM_001356814.3 → NP_001343711.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2V3

Conserved Domains (8) summary

cd04972
Location:1602 → 1691

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00060
Location:5229 → 5312

FN3; Fibronectin type 3 domain

cd00063
Location:6575 → 6670

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:175 → 264

I-set; Immunoglobulin I-set domain

cd14109
Location:5574 → 5832

PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cd14112
Location:6735 → 6989

STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cl26511
Location:831 → 1519

Neuromodulin_N; Gap junction protein N-terminal region

cl28434
Location:473 → 561

I-set; Immunoglobulin I-set domain
NM_001356815.3 → NP_001343712.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2V5

Conserved Domains (8) summary

cd04972
Location:1580 → 1669

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00060
Location:5780 → 5863

FN3; Fibronectin type 3 domain

cd00063
Location:7126 → 7221

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:175 → 264

I-set; Immunoglobulin I-set domain

cd14109
Location:6125 → 6383

PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cd14112
Location:7286 → 7540

STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cl26511
Location:850 → 1497

Neuromodulin_N; Gap junction protein N-terminal region

cl28434
Location:473 → 561

I-set; Immunoglobulin I-set domain
NM_001356816.3 → NP_001343713.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C332

Conserved Domains (7) summary

cd04972
Location:962 → 1051

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00060
Location:5162 → 5245

FN3; Fibronectin type 3 domain

cd00063
Location:6508 → 6603

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:175 → 264

I-set; Immunoglobulin I-set domain

cd14112
Location:6668 → 6922

STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cl21453
Location:5507 → 5765

PKc_like; Protein Kinases, catalytic domain

cl28434
Location:869 → 955

I-set; Immunoglobulin I-set domain
NM_001306525.3 → NP_001293454.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293454.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01761

Conserved Domains (6) summary

smart00220
Location:1108 → 1350

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00063
Location:936 → 1031

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:843 → 931

I-set; Immunoglobulin I-set domain

cd14112
Location:1096 → 1350

STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cl11960
Location:861 → 931

Ig; Immunoglobulin domain

cl21453
Location:12 → 193

PKc_like; Protein Kinases, catalytic domain
NM_001306524.2 → NP_001293453.1 Muscle M-line assembly protein unc-89 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001293453.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01761

Conserved Domains (6) summary

smart00220
Location:1105 → 1347

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd00063
Location:933 → 1028

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:840 → 928

I-set; Immunoglobulin I-set domain

cd14112
Location:1093 → 1347

STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89

cl11960
Location:858 → 928

Ig; Immunoglobulin domain

cl21453
Location:9 → 190

PKc_like; Protein Kinases, catalytic domain