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    spsb-2 SPRY domain-containing SOCS box protein 1 [ Caenorhabditis elegans ]

    Gene ID: 266877, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spsb-2
    Official Full Name
    SPRY domain-containing SOCS box protein 1
    Primary source
    WormBase:WBGene00021596
    Locus tag
    CELE_Y46E12BL.3
    See related
    AllianceGenome:WB:WBGene00021596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in hypodermis and intestine. Orthologous to several human genes including SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spsb-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (15230343..15232803)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene B30.2/SPRY domain-containing protein;SPRY domain-containing SOCS box protein 1;SPRY domain-containing SOCS box protein 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal RNA-processing protein 12-like conserved domain-containing protein Neighboring gene TGF-beta family profile domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    2. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SPRY domain-containing SOCS box protein 1
    NP_497320.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      15230343..15232803
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064919.7 → NP_497320.2  SPRY domain-containing SOCS box protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497320.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q965N7
      Conserved Domains (2) summary
      cd03718
      Location:200 → 241
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cd12906
      Location:25 → 194
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)
    Nucleotide Protein
    Heading Accession and Version

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