lid-1 AB hydrolase-1 domain-containing protein;Abhydrolase domain-containing protein lid-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lid-1
Official Full Name: AB hydrolase-1 domain-containing protein;Abhydrolase domain-containing protein lid-1
Primary source: WormBase:WBGene00007711
Locus tag: CELE_C25A1.12
See related: AllianceGenome:WB:WBGene00007711
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable carboxylic ester hydrolase activity and lysophosphatidic acid acyltransferase activity. Predicted to be involved in lipid homeostasis and phosphatidic acid biosynthetic process. Located in lipid droplet. Is expressed in intestinal cell. Used to study Chanarin-Dorfman syndrome. Human ortholog(s) of this gene implicated in Chanarin-Dorfman syndrome; autosomal recessive congenital ichthyosis 1; and colon adenocarcinoma. Orthologous to human ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B) and ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid acyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lid-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (10191273..10192832, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the intestinal cells of C. elegans, a newly identified protein, lipid droplet protein 1 (C25A1.12; LID-1), modulates lipolysis by binding to adipose triglyceride lipase 1 (C05D11.7; ATGL-1) during nutritional deprivation.
Title: Lipid droplet protein LID-1 mediates ATGL-1-dependent lipolysis during fasting in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C25A1.12 (e-PCR)
- UniSTS:306505

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: AB hydrolase-1 domain-containing protein;Abhydrolase domain-containing protein lid-1

NP_001348662.1

Confirmed by transcript evidence

NP_001348663.1

Confirmed by transcript evidence

NP_001348664.1

Confirmed by transcript evidence

NP_492685.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10191273..10192832 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060284.4 → NP_492685.2 Abhydrolase domain-containing protein lid-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492685.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O02218

Conserved Domains (2) summary

COG0596
Location:71 → 343

MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

pfam12695
Location:73 → 175

Abhydrolase_5; Alpha/beta hydrolase family
NM_001361833.2 → NP_001348662.1 AB hydrolase-1 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2K5ATL7

Conserved Domains (1) summary

PLN02894
Location:58 → 360

PLN02894; hydrolase, alpha/beta fold family protein
NM_001361834.3 → NP_001348664.1 AB hydrolase-1 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2K5ATL6

Conserved Domains (1) summary

PLN02894
Location:11 → 308

PLN02894; hydrolase, alpha/beta fold family protein
NM_001361835.3 → NP_001348663.1 AB hydrolase-1 domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2K5ATM4

Conserved Domains (1) summary

PLN02894
Location:11 → 313

PLN02894; hydrolase, alpha/beta fold family protein