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    tbc-11 Rab GTPase-activating protein tbc-11 [ Caenorhabditis elegans ]

    Gene ID: 180444, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbc-11
    Official Full Name
    Rab GTPase-activating protein tbc-11
    Primary source
    WormBase:WBGene00018075
    Locus tag
    CELE_F35H12.2
    See related
    AllianceGenome:WB:WBGene00018075
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in RNA localization and cuticle development. Is expressed in several structures, including hermaphrodite gonad; intestine; nervous system; pharyngeal-intestinal valve; and rectal gland cell. Orthologous to human RABGAP1 (RAB GTPase activating protein 1) and RABGAP1L (RAB GTPase activating protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tbc-11 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    19
    Sequence:
    Chromosome: X; NC_003284.9 (924958..932261)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Phosphatidylinositol 4-kinase beta Neighboring gene Schwannomin interacting protein 1 C-terminal domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans. Michaud P, et al. PLoS Genet, 2021 Apr. PMID 33826611, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans.
      Title: The RabGAP TBC-11 controls Argonaute localization for proper microRNA function in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rab GTPase-activating protein tbc-11
    NP_001360743.1
    • Partially confirmed by transcript evidence
    NP_001367822.1
    • Confirmed by transcript evidence
    NP_508178.2
    • Partially confirmed by transcript evidence
    NP_508179.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      924958..932261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075778.5 → NP_508179.2  Rab GTPase-activating protein tbc-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508179.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZZ5
      Conserved Domains (4) summary
      smart00164
      Location:419 → 628
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:693 → 897
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12473
      Location:183 → 293
      DUF3694; Kinesin protein
      cl17171
      Location:11 → 147
      PH-like; Pleckstrin homology-like domain

    2. NM_001373217.4 → NP_001360743.1  Rab GTPase-activating protein tbc-11 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (4) summary
      smart00164
      Location:421 → 630
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:695 → 899
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12473
      Location:183 → 293
      DUF3694; Kinesin protein
      cl17171
      Location:11 → 147
      PH-like; Pleckstrin homology-like domain

    3. NM_075777.7 → NP_508178.2  Rab GTPase-activating protein tbc-11 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508178.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A4V0IKC0, H2KZZ5, H2KZZ6, Q5LK42
      Conserved Domains (4) summary
      smart00164
      Location:419 → 632
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:697 → 901
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam12473
      Location:183 → 293
      DUF3694; Kinesin protein
      cl17171
      Location:11 → 147
      PH-like; Pleckstrin homology-like domain

    4. NM_001380899.2 → NP_001367822.1  Rab GTPase-activating protein tbc-11 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      smart00164
      Location:60 → 269
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:334 → 538
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    Nucleotide Protein
    Heading Accession and Version

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