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    polk-1 DNA polymerase kappa [ Caenorhabditis elegans ]

    Gene ID: 176209, updated on 9-Dec-2024

    Summary

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    Official Symbol
    polk-1
    Official Full Name
    DNA polymerase kappa
    Primary source
    WormBase:WBGene00017696
    Locus tag
    CELE_F22B7.6
    See related
    AllianceGenome:WB:WBGene00017696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-directed DNA polymerase activity. Involved in embryo development and error-prone translesion synthesis. Predicted to be active in nucleus. Orthologous to human POLK (DNA polymerase kappa). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See polk-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (8626258..8628590, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Homeobox protein engrailed-like ceh-16 Neighboring gene G-protein regulator 1 Neighboring gene DnaJ homolog dnj-10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites. Koole W, et al. Nat Commun, 2014. PMID 24496117
    2. Preservation of lagging strand integrity at sites of stalled replication by Pol α-primase and 9-1-1 complex. van Schendel R, et al. Sci Adv, 2021 May. PMID 34138739, Free PMC Article
    3. Homologous recombination is required for genome stability in the absence of DOG-1 in Caenorhabditis elegans. Youds JL, et al. Genetics, 2006 Jun. PMID 16547095, Free PMC Article
    4. A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis. Roerink SF, et al. PLoS Genet, 2012 Jun. PMID 22761594, Free PMC Article
    5. Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos. Holway AH, et al. J Cell Biol, 2006 Mar 27. PMID 16549501, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUMO-mediated regulation of both POLH-1 and POLK-1, and point towards a previously unrecognized role of the nuclear pore in regulating Translesion synthesis .
      Title: A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in error-prone translesion synthesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in error-prone translesion synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in translesion synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase kappa
    NP_001122692.1
    • Confirmed by transcript evidence
    NP_001379588.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8626258..8628590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129220.3 → NP_001122692.1  DNA polymerase kappa [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122692.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8WFE8, A8WFE9, P34409
      Conserved Domains (2) summary
      cd03586
      Location:86 → 473
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
      PRK02406
      Location:90 → 473
      PRK02406; DNA polymerase IV; Validated

    2. NM_001392159.1 → NP_001379588.1  DNA polymerase kappa [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd03586
      Location:1 → 340
      PolY_Pol_IV_kappa; DNA Polymerase IV/Kappa
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34409.3

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