fld-1 TLC domain-containing protein fld-1 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: fld-1
Official Full Name: TLC domain-containing protein fld-1
Primary source: WormBase:WBGene00013407
Locus tag: CELE_Y63D3A.8
See related: AllianceGenome:WB:WBGene00013407
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. Is expressed widely. Orthologous to human TLCD2 (TLC domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See fld-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (14114194..14118650)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

inhibition of FLD-1 or TLCD1/2 prevents lipotoxicity by allowing increased levels of membrane phospholipids that contain fluidizing long-chain polyunsaturated fatty acids.
Title: Membrane fluidity is regulated by the C. elegans transmembrane protein FLD-1 and its human homologs TLCD1/2.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

STS1-220 (e-PCR)
- UniSTS:241714

Y63D3A.8 (e-PCR)
- UniSTS:320419

Y63D3A.7 (e-PCR)
- UniSTS:320766

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane lipid distribution	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane lipid distribution	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: TLC domain-containing protein fld-1

NP_493466.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14114194..14118650

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061065.8 → NP_493466.2 TLC domain-containing protein fld-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493466.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EF48

Conserved Domains (1) summary

smart00724
Location:102 → 295

TLC; TRAM, LAG1 and CLN8 homology domains