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    set-23 putative histone-lysine N-methyltransferase set-23 [ Caenorhabditis elegans ]

    Gene ID: 176969, updated on 9-Dec-2024

    Summary

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    Official Symbol
    set-23
    Official Full Name
    putative histone-lysine N-methyltransferase set-23
    Primary source
    WormBase:WBGene00021515
    Locus tag
    CELE_Y41D4B.12
    See related
    AllianceGenome:WB:WBGene00021515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable double-stranded DNA binding activity and histone methyltransferase activity. Predicted to be involved in chromatin remodeling and methylation. Predicted to be located in chromosome and nucleus. Is expressed in germ line and hypodermis. Orthologous to human SETMAR (SET domain and mariner transposase fusion gene). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See set-23 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (1602985..1605609)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Nucleoporin Nup133/Nup155-like C-terminal domain-containing protein;Nucleoporin Nup133/Nup155-like N-terminal domain-containing protein;Nucleoporin_N domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Cell death abnormality protein 2;SH3 domain-containing protein Neighboring gene DUF1014-domain-containing protein Neighboring gene Delta-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. P Granules Protect RNA Interference Genes from Silencing by piRNAs. Ouyang JPT, et al. Dev Cell, 2019 Sep 23. PMID 31402283, Free PMC Article
    2. Antagonistic functions of SET-2/SET1 and HPL/HP1 proteins in C. elegans development. Simonet T, et al. Dev Biol, 2007 Dec 1. PMID 17967446
    3. Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development. Andersen EC, et al. Development, 2007 Aug. PMID 17634190
    4. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806
    5. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K9 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative histone-lysine N-methyltransferase set-23
    NP_741320.1
    • Confirmed by transcript evidence
    NP_741321.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      1602985..1605609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171270.2 → NP_741320.1  putative histone-lysine N-methyltransferase set-23 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741320.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MXT0, Q95Y12
      Conserved Domains (2) summary
      smart00317
      Location:89 → 213
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      pfam05033
      Location:6 → 81
      Pre-SET; Pre-SET motif

    2. NM_171271.7 → NP_741321.1  putative histone-lysine N-methyltransferase set-23 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741321.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95Y12
      Conserved Domains (1) summary
      smart00317
      Location:16 → 128
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95Y12.1

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