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    ddx-27 RNA helicase [ Caenorhabditis elegans ]

    Gene ID: 171743, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ddx-27
    Official Full Name
    RNA helicase
    Primary source
    WormBase:WBGene00022148
    Locus tag
    CELE_Y71G12B.8
    See related
    AllianceGenome:WB:WBGene00022148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Predicted to be located in P granule. Predicted to be active in nucleolus. Orthologous to human DDX27 (DEAD-box helicase 27). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ddx-27 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (1767887..1790157)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene hydroxymethylglutaryl-CoA lyase Neighboring gene ML domain-containing protein;RING-type domain-containing protein;Uncharacterized protein Neighboring gene MFS domain-containing protein;Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene MFS domain-containing protein Neighboring gene ncRNA Neighboring gene NAD(P)-bd_dom domain-containing protein;NAD(P)-binding domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Macrorestriction analysis of Caenorhabditis elegans genomic DNA. Browning H, et al. Genetics, 1996 Oct. PMID 8889524, Free PMC Article
    2. Two types of sites required for meiotic chromosome pairing in Caenorhabditis elegans. McKim KS, et al. Genetics, 1993 Jul. PMID 8349107, Free PMC Article
    3. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article
    4. Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Johnsen RC, et al. Mol Gen Genet, 2000 Mar. PMID 10778742
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in P granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA helicase
    NP_490891.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1767887..1790157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058490.5 → NP_490891.2  RNA helicase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490891.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95XM9
      Conserved Domains (3) summary
      COG0513
      Location:128 → 609
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00268
      Location:150 → 354
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:379 → 488
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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