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    spsb-1 B30.2/SPRY domain-containing protein;SPRY domain-containing SOCS box protein 1;SPRY domain-containing SOCS box protein 4 [ Caenorhabditis elegans ]

    Gene ID: 266876, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spsb-1
    Official Full Name
    B30.2/SPRY domain-containing protein;SPRY domain-containing SOCS box protein 1;SPRY domain-containing SOCS box protein 4
    Primary source
    WormBase:WBGene00021597
    Locus tag
    CELE_Y46E12BL.4
    See related
    AllianceGenome:WB:WBGene00021597
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in hypodermis; interfacial epithelial cell; intestine; and pharyngeal muscle cell. Orthologous to human SPSB1 (splA/ryanodine receptor domain and SOCS box containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spsb-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (15196733..15229725)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Glutathione S-Transferase Neighboring gene Glutathione transferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal RNA-processing protein 12-like conserved domain-containing protein Neighboring gene SPRY domain-containing SOCS box protein 1 Neighboring gene TGF-beta family profile domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    B30.2/SPRY domain-containing protein;SPRY domain-containing SOCS box protein 1;SPRY domain-containing SOCS box protein 4
    NP_001293563.1
    • Confirmed by transcript evidence
    NP_001364518.1
    • Confirmed by transcript evidence
    NP_001364817.1
    • Confirmed by transcript evidence
    NP_001364818.1
    • Confirmed by transcript evidence
    NP_001368256.1
    • Confirmed by transcript evidence
    NP_001368257.1
    • Confirmed by transcript evidence
    NP_001380140.1
    • Confirmed by transcript evidence
    NP_001380141.1
    • Confirmed by transcript evidence
    NP_497321.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      15196733..15229725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377908.2 → NP_001364518.1  SPRY domain-containing SOCS box protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9MNQ7
      Conserved Domains (2) summary
      cd03718
      Location:355 → 396
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cd12906
      Location:178 → 350
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    2. NM_001393240.1 → NP_001380141.1  SPRY domain-containing SOCS box protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRE9
      Conserved Domains (2) summary
      cd03718
      Location:310 → 351
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cd12906
      Location:133 → 305
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    3. NM_001381674.1 → NP_001368256.1  SPRY domain-containing SOCS box protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBC8
      Conserved Domains (2) summary
      cd03718
      Location:308 → 349
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cd12906
      Location:131 → 303
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    4. NM_064920.7 → NP_497321.3  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497321.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4RQA5, Q965N6
      Conserved Domains (1) summary
      cd12906
      Location:131 → 303
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    5. NM_001377910.2 → NP_001364818.1  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEK0
      Conserved Domains (2) summary
      cd03718
      Location:371 → 412
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cd12906
      Location:194 → 366
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    6. NM_001381675.1 → NP_001368257.1  B30.2/SPRY domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBQ5
      Conserved Domains (2) summary
      cd03718
      Location:369 → 410
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cd12906
      Location:192 → 364
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    7. NM_001393241.1 → NP_001380140.1  SPRY domain-containing SOCS box protein 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBC3
      Conserved Domains (2) summary
      cd03718
      Location:423 → 464
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cd12906
      Location:246 → 418
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    8. NM_001306634.3 → NP_001293563.1  SPRY domain-containing SOCS box protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293563.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PM56
      Conserved Domains (2) summary
      cd03718
      Location:425 → 466
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cd12906
      Location:248 → 420
      SPRY_SOCS1-2-4; SPRY domain in the suppressor of cytokine signaling 1, 2, 4 families (SOCS1, SOCS2, SOCS4)

    9. NM_001377912.2 → NP_001364817.1  SPRY domain-containing SOCS box protein 4 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBQ2
      Conserved Domains (2) summary
      cd03718
      Location:141 → 182
      SOCS_SSB1_4; SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor ...
      cl02614
      Location:1 → 136
      SPRY; SPRY domain
    Nucleotide Protein
    Heading Accession and Version

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