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    vps-4 vesicle-fusing ATPase [ Caenorhabditis elegans ]

    Gene ID: 189590, updated on 9-Dec-2024

    Summary

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    Official Symbol
    vps-4
    Official Full Name
    vesicle-fusing ATPase
    Primary source
    WormBase:WBGene00021334
    Locus tag
    CELE_Y34D9A.10
    See related
    AllianceGenome:WB:WBGene00021334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP hydrolysis activity. Involved in mechanosensory behavior and protein localization to postsynaptic membrane. Predicted to be located in endosome membrane. Orthologous to human VPS4A (vacuolar protein sorting 4 homolog A) and VPS4B (vacuolar protein sorting 4 homolog B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See vps-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (1053894..1066899, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene PSP domain-containing protein;PSP proline-rich domain-containing protein Neighboring gene Glutaredoxin-1 Neighboring gene Conserved plasma membrane protein;Low-density lipoprotein receptor domain class A;Transmembrane protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Guanine nucleotide-binding protein G(s) subunit alpha Neighboring gene Uncharacterized protein Neighboring gene Autophagy-related protein 9;RGS domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UNC-108/Rab2 regulates postendocytic trafficking in Caenorhabditis elegans. Chun DK, et al. Mol Biol Cell, 2008 Jul. PMID 18434599, Free PMC Article
    2. Dominant-negative VPS-4 disrupts ODR-10::GFP distribution but has limited effects on chemotaxis. Zocher E, et al. MicroPubl Biol, 2018 Aug 2. PMID 32550384, Free PMC Article
    3. The ESCRT-III protein CeVPS-32 is enriched in domains distinct from CeVPS-27 and CeVPS-23 at the endosomal membrane of epithelial cells. Michelet X, et al. Biol Cell, 2009 Jul 31. PMID 19432559
    4. The C. elegans homologue of the spastic paraplegia protein, spastin, disassembles microtubules. Matsushita-Ishiodori Y, et al. Biochem Biophys Res Commun, 2007 Jul 20. PMID 17531954
    5. Induction of autophagy in ESCRT mutants is an adaptive response for cell survival in C. elegans. Djeddi A, et al. J Cell Sci, 2012 Feb 1. PMID 22389403

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to postsynaptic membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vesicle-fusing ATPase
    NP_490816.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1053894..1066899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058415.9 → NP_490816.4  vesicle-fusing ATPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490816.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL83
      Conserved Domains (5) summary
      smart00382
      Location:150 → 286
      AAA; ATPases associated with a variety of cellular activities
      cd02678
      Location:4 → 79
      MIT_VPS4; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This sub-family of MIT domains is found in intracellular protein transport proteins of the AAA-ATPase family. The molecular function of the MIT domain is unclear.
      pfam00004
      Location:154 → 284
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:365 → 425
      Vps4_C; Vps4 C terminal oligomerization domain
      cl21455
      Location:117 → 185
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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