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    tcl-2 T-cell defective protein 2 [ Caenorhabditis elegans ]

    Gene ID: 176832, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tcl-2
    Official Full Name
    T-cell defective protein 2
    Primary source
    WormBase:WBGene00006561
    Locus tag
    CELE_Y38C1AA.4
    See related
    AllianceGenome:WB:WBGene00006561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in asymmetric cell division. Located in cytoplasm and nucleus. Is expressed in several structures, including TL.a; TL.p; TR.a; inner labial neurons; and seam cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tcl-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (179083..183254)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ZP domain-containing protein Neighboring gene ncRNA Neighboring gene nicotinamidase Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene COP9 signalosome complex subunit 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C. elegans. Zhao X, et al. Dev Biol, 2003 Apr 15. PMID 12679102
    2. A novel biochemical method to identify target genes of individual microRNAs: identification of a new Caenorhabditis elegans let-7 target. Andachi Y. RNA, 2008 Nov. PMID 18824511, Free PMC Article
    3. Wnt signaling. Eisenmann DM. WormBook, 2005 Jun 25. PMID 18050402, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functions with Wnt pathways to control T cell fate specification, gonad development, and P12 cell fate specification.
      Title: tcl-2 encodes a novel protein that acts synergistically with Wnt signaling pathways in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-cell defective protein 2
    NP_001294305.1
    • Confirmed by transcript evidence
    NP_499875.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      179083..183254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067474.7 → NP_499875.2  T-cell defective protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499875.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N428

    2. NM_001307376.3 → NP_001294305.1  T-cell defective protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PB86
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N428.3

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