sut-2 Zinc finger CCCH domain-containing protein 14 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sut-2
Official Full Name: Zinc finger CCCH domain-containing protein 14
Primary source: WormBase:WBGene00022019
Locus tag: CELE_Y61A9LA.8
See related: AllianceGenome:WB:WBGene00022019
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable poly(A) binding activity. Predicted to be involved in regulation of mRNA stability. Located in nucleus and perinuclear region of cytoplasm. Is expressed in germ line; hypodermis; and intestine. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 56. Orthologous to human ZC3H14 (zinc finger CCCH-type containing 14). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sut-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (4562020..4570049, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified sut-2 as a gene required for tau neurotoxicity in C. elegans and cloned the sut-2 gene and found it encodes a novel sub-type of CCCH zinc finger protein conserved across animal phyla.
Title: SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y61A9LA_68.a (e-PCR)
- UniSTS:323181

Y61A9LA_72.a (e-PCR)
- UniSTS:323188

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A) binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of mRNA stability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA stability	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Zinc finger CCCH domain-containing protein 14

NP_001360618.1

Partially confirmed by transcript evidence

NP_504239.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

4562020..4570049 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001373021.2 → NP_001360618.1 Zinc finger CCCH domain-containing protein 14 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4V0IN13

Conserved Domains (3) summary

pfam14608
Location:695 → 710

zf-CCCH_2; RNA-binding, Nab2-type zinc finger

pfam15663
Location:506 → 559

zf-CCCH_3; Zinc-finger containing family

cl02562
Location:15 → 83

PWI; PWI domain
NM_071838.8 → NP_504239.2 Zinc finger CCCH domain-containing protein 14 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_504239.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95XU6

Conserved Domains (4) summary

pfam14608
Location:525 → 542

zf-CCCH_2; RNA-binding, Nab2-type zinc finger

pfam15663
Location:506 → 559

zf-CCCH_3; Zinc-finger containing family

pfam16031
Location:594 → 661

TonB_N; TonB N-terminal region

cl02562
Location:15 → 83

PWI; PWI domain